NZOZ Pachońscy Dental Clinic Marek Pachoński, Tarnowskie Gory, Poland.
Department of Conservative Dentistry with Endodontics, Faculty of Medical Science, Medical University of Silesia, Katowice, Poland.
Pediatr Endocrinol Diabetes Metab. 2021;27(2):100-108. doi: 10.5114/pedm.2021.104343.
The oral cavity is a unique ecosystem in which the microbiome is formed by the colonization of billions of bacteria, viruses, and fungi. Aim of the study was to assess the quality and quantity of bacterial microbiota of the oral cavity in children with type 1 diabetes in comparison to healthy children.
The study group consisted of 50 randomly selected type 1 diabetic children aged 10-18 years divided into 2 groups (25 people each) according to the level of diabetes control: well-controlled group (WC) - HbA1c ≤ 7.5%) and poorly-controlled group (PC) - HbA1c > 7.5%. The control group (GC) consisted of 25 randomly selected children with no systemic diseases. The material for microbiological tests was collected as two swabs: one from the bottom of the oral cavity and the other one from the posterior part of the dorsum of the tongue).
The statistical analysis revealed statistically significant differences in the total number of isolated microorganisms between PC and GC (post hoc test p = 0.003) and WC and GC (post hoc test p < 0.001). There were no statistically significant differences in the number of isolated microorganisms between PC and WC (p = 0.195).
Oral microbiome in type 1 diabetic children is significantly quantitatively different in comparison to healthy children. There are also visible qualitative differences in the profile of oral microbiota in type 1 diabetic children and healthy children.
口腔是一个独特的生态系统，其中微生物组是由数十亿细菌、病毒和真菌的定植形成的。本研究旨在评估 1 型糖尿病儿童与健康儿童口腔细菌微生物群落的质量和数量。
研究组由 50 名随机选择的 10-18 岁 1 型糖尿病儿童组成，根据糖尿病控制水平分为 2 组（每组 25 人）：血糖控制良好组（WC，HbA1c≤7.5%）和血糖控制不佳组（PC，HbA1c＞7.5%）。对照组（GC）由 25 名随机选择的无系统疾病的儿童组成。微生物学测试的材料采集为两个拭子：一个来自口腔底部，另一个来自舌背后部。
统计分析显示，PC 与 GC 之间（事后检验 p=0.003）和 WC 与 GC 之间（事后检验 p<0.001）的总分离微生物数量存在统计学显著差异。PC 与 WC 之间的分离微生物数量无统计学显著差异（p=0.195）。
与健康儿童相比，1 型糖尿病儿童的口腔微生物组在数量上有明显差异。1 型糖尿病儿童和健康儿童的口腔微生物群落的特征也存在明显的差异。
