义齿佩戴者口腔白色念珠菌的发生率。

Occurrence rate of oral Candida albicans in denture wearer patients.

作者信息

Daniluk T, Tokajuk G, Stokowska W, Fiedoruk K, Sciepuk M, Zaremba M L, Rozkiewicz D, Cylwik-Rokicka D, Kedra B A, Anielska I, Górska M, Kedra B R

机构信息

Department of Microbiology, Medical University of Białystok, Poland.

出版信息

Adv Med Sci. 2006;51 Suppl 1:77-80.

PMID:17458064

Abstract

PURPOSE

The aim was to determine the fungi occurrence rate in the oral cavity of denture wearer patients in comparison to those without dentures.

MATERIAL AND METHODS

The examinations were conducted in patients treated in two clinical departments of the University Hospital. Demographic data and those connected with basic diseases were collected and the evaluation concerning dentition and oral hygiene was performed. Samples for mycological examinations from the tongue dorsa, palatal mucosa, and mucosal surfaces of dentures were collected from patients with dentures while tongue and palate swabs were taken from those without dentures. For culture and identify of fungi standard methods were used.

RESULTS

Dental and mycological examinations were performed in 95 patients, out of which 57 (60.0%) used complete or partial dentures and 38 (40.0%) had their own dentition (without dentures). Oral cavity revealed only growth of Candida albicans species, more frequently in patients with dentures (38/57; 66.7%) than in those without dentures (11/ 38; 28.9%) (p = 0.0003). C. albicans statistically significantly more frequently was isolated in denture wearer patients with diabetes mellitus (p = 0.0207) and without diabetes (p = 0.0376) comparing to such groups of patients but without dentures. Among 32 patients with diabetes mellitus, 14 (43.8%) revealed C. albicans; this rate was comparable with 9/23 (39.1%) patients without diabetes (p > 0.05). A similar analysis, conducted in 25 surgical patients with abdominal cancer and 15--without--cancers, did not show statistically significant differences in the incidence rate of C. albicans; it also concerned denture wearers (14/16; 87.5%) and non-wearing dentures (5/9; 55.6%) (p > 0.05) with cancer. In 37 (64.9%) wearer patients denture stomatitis was observed, associated mainly with C. albicans infections (29/37; 78.4%).

CONCLUSIONS

Mycological findings from the present study do not indicate that diabetes mellitus or advanced cancer has a significant effect on oral colonisation by Candida albicans or other species of Candida genus. 2) The occurrence rate of oral Candida albicans in patients with dentures (diabetic and non-diabetic, cancer and non-cancer patients) was higher than in patients without dentures (p < 0.05).

摘要

目的

旨在确定佩戴假牙患者与未佩戴假牙患者口腔中真菌的发生率。

材料与方法

检查在大学医院的两个临床科室接受治疗的患者中进行。收集人口统计学数据以及与基础疾病相关的数据，并对牙列和口腔卫生进行评估。从佩戴假牙的患者的舌背、腭黏膜和假牙黏膜表面采集真菌学检查样本，而从未佩戴假牙的患者采集舌和腭拭子。采用标准方法进行真菌培养和鉴定。

结果

对95例患者进行了牙科和真菌学检查，其中57例（60.0%）使用全口或局部假牙，38例（40.0%）有自己的牙列（未佩戴假牙）。口腔中仅发现白色念珠菌生长，佩戴假牙的患者中更为常见（38/57；66.7%），高于未佩戴假牙的患者（11/38；28.9%）（p = 0.0003）。与未佩戴假牙的同类患者相比，佩戴假牙的糖尿病患者（p = 0.0207）和非糖尿病患者（p = 0.0376）中白色念珠菌的分离率在统计学上显著更高。在32例糖尿病患者中，14例（43.8%）发现白色念珠菌；该比率与23例非糖尿病患者中的9例（39.1%）相当（p > 0.05）。在25例腹部癌症手术患者和15例非癌症患者中进行的类似分析显示，白色念珠菌的发生率在统计学上没有显著差异；这也涉及佩戴假牙的患者（14/16；87.5%）和未佩戴假牙的癌症患者（5/9；55.6%）（p > 0.05）。在37例（64.9%）佩戴假牙的患者中观察到义齿性口炎，主要与白色念珠菌感染有关（29/37；78.4%）。