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癫痫的历史:从古代谜团到现代误解

The History of Epilepsy: From Ancient Mystery to Modern Misconception.

作者信息

Kaculini Christian M, Tate-Looney Amelia J, Seifi Ali

机构信息

Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, USA.

Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, USA.

出版信息

Cureus. 2021 Mar 17;13(3):e13953. doi: 10.7759/cureus.13953.

DOI:10.7759/cureus.13953
PMID:33880289
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8051941/
Abstract

Epilepsy is an ancient disease, which has fascinated and frightened scientists and laymen alike. Before the working knowledge of the central nervous system, seizures were shrouded in mystery. In antiquity, this disease was accredited to gods and demonic possession, causing those with epilepsy to be feared and isolated. Epilepsy patients continued to face discrimination through the mid-20th century. This discrimination ranged from lack of access to health insurance, jobs, and marriage equality to forced sterilizations. Despite the strides that have been made, there are still many misconceptions globally regarding epilepsy. Studies show that patients with epilepsy in communities that understand the pathology and cause of seizures are generally more successful in social and educational environments. While there has been progress, there is more work which needs to be done to educate people across the globe about the pathology of epilepsy.

摘要

癫痫是一种古老的疾病,它既让科学家着迷,也让外行人感到恐惧。在对中枢神经系统有深入了解之前,癫痫发作一直笼罩在神秘之中。在古代,这种疾病被归咎于神灵和恶魔附身,导致癫痫患者被恐惧和孤立。直到20世纪中叶,癫痫患者仍面临歧视。这种歧视包括无法获得医疗保险、工作机会、婚姻平等,甚至被强制绝育。尽管已经取得了一些进展,但全球范围内对癫痫仍存在许多误解。研究表明,在了解癫痫发作病理和病因的社区中,癫痫患者在社会和教育环境中通常表现得更为出色。虽然已经取得了进步,但仍有更多工作要做,以让全球各地的人们了解癫痫的病理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ed/8051941/47ec0bf7fc63/cureus-0013-00000013953-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ed/8051941/2ce6dd27417a/cureus-0013-00000013953-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ed/8051941/47ec0bf7fc63/cureus-0013-00000013953-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ed/8051941/2ce6dd27417a/cureus-0013-00000013953-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/36ed/8051941/47ec0bf7fc63/cureus-0013-00000013953-i02.jpg

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Sex-specific proteomic analysis of epileptic brain tissues from Pten knockout mice and human refractory epilepsy.对Pten基因敲除小鼠和人类难治性癫痫患者的癫痫脑组织进行性别特异性蛋白质组学分析。
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本文引用的文献

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The evolution of the concepts of seizures and epilepsy: What's in a name?癫痫发作与癫痫概念的演变:名称中蕴含着什么?
Epilepsia Open. 2020 Jan 10;5(1):22-35. doi: 10.1002/epi4.12375. eCollection 2020 Mar.
2
Samuel Tissot's -250 years old.塞缪尔·蒂索特享年250岁。 (不过从常理来说,人不太可能活到250岁,此句可能存在信息偏差或表述有误等情况 )
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Experiences and needs of parents of young children with active epilepsy: A population-based study.活动性癫痫幼儿家长的经历与需求:一项基于人群的研究。
药剂师在加强癫痫护理中的作用:对社区和门诊干预措施的系统评价
J Pharm Policy Pract. 2025 Apr 10;18(1):2487046. doi: 10.1080/20523211.2025.2487046. eCollection 2025.
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Knowledge, attitudes and practices of the Saudi population toward people with epilepsy: narrow or wide?沙特民众对癫痫患者的认知、态度和行为:范围狭窄还是广泛?
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Epilepsy in Asian countries.亚洲国家的癫痫
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A real-world pharmacovigilance analysis of eslicarbazepine acetate using the FDA adverse events reporting system (FAERS) database from 2013 (Q4) to 2024 (Q1).一项使用美国食品药品监督管理局不良事件报告系统(FAERS)数据库,对2013年第四季度至2024年第一季度醋酸艾司利卡西平进行的真实世界药物警戒分析。
Front Pharmacol. 2024 Sep 20;15:1463560. doi: 10.3389/fphar.2024.1463560. eCollection 2024.
7
Epinephrine, Pregabalin, and Crizotinib as Three Medicines with Polish Implications over Three Last Centuries and in View of Three Different Drug Discovery Approaches.肾上腺素、普瑞巴林和克唑替尼:过去三个世纪对波兰有影响的三种药物及三种不同的药物发现方法
Biomedicines. 2024 Sep 4;12(9):2021. doi: 10.3390/biomedicines12092021.
8
Biomechanical Effects of Seizures on Cerebral Dynamics and Brain Stress.癫痫发作对脑动力学和脑应激的生物力学影响。
Brain Sci. 2024 Mar 27;14(4):323. doi: 10.3390/brainsci14040323.
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Schiff Bases: A Captivating Scaffold with Potential Anticonvulsant Activity.席夫碱:一种具有潜在抗惊厥活性的迷人支架。
Mini Rev Med Chem. 2024;24(18):1632-1650. doi: 10.2174/0113895575302197240408121537.
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Knowledge and Attitudes towards Epilepsy of Croatian General Student Population and Biomedical Students: A Cross-Sectional Study.克罗地亚普通学生群体和生物医学专业学生对癫痫的认知与态度:一项横断面研究。
Healthcare (Basel). 2023 Sep 14;11(18):2550. doi: 10.3390/healthcare11182550.
Epilepsy Behav. 2019 Jan;90:37-44. doi: 10.1016/j.yebeh.2018.10.031. Epub 2018 Nov 27.
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Hallmarks in 18th- and 19th-century epilepsy research.18 世纪和 19 世纪癫痫研究的特征。
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