综合方法确定了位于3p21.31基因座的COVID-19全基因组关联研究信号的假定因果基因。
Integrative approach identifies and as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus.
作者信息
Kasela Silva, Daniloski Zharko, Jordan Tristan X, tenOever Benjamin R, Sanjana Neville E, Lappalainen Tuuli
机构信息
New York Genome Center, New York, NY, USA.
Department of Systems Biology, Columbia University, New York, NY, USA.
出版信息
medRxiv. 2021 Apr 13:2021.04.09.21255184. doi: 10.1101/2021.04.09.21255184.
To date the locus with the most robust human genetic association to COVID-19 susceptibility is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify and as putative causal genes that mediate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between and studies of human biology.
迄今为止，与新冠病毒易感性存在最显著人类遗传关联的基因座位于3号染色体短臂21.31区域。在此，我们整合了全基因组规模的CRISPR功能丧失筛选以及不同细胞类型和组织中的表达定量性状基因座（eQTL），以确定新冠病毒风险背后的基因。我们的研究结果确定了[具体基因1]和[具体基因2]作为介导新冠病毒风险的假定因果基因，并突出了这种整合方法在弥合人类生物学[两方面研究]之间差距方面的有用性。 （注：原文中“ and ”处应补充具体信息，译文按原文格式保留以便对照）
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