3p21.31 基因座（CXCR6 和 LZTFL1）与巴西住院 COVID-19 患者结局的关联。
Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects.
机构信息
Grupo de Pesquisa em Bioestatística e Epidemiologia Molecular, Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Departamento de Nutrição, Escola de Enfermagem, Universidade Federal de Minas Gerais, Minas Gerais - Brazil, Belo Horizonte, MG, Brazil.
出版信息
Curr Microbiol. 2023 Aug 14;80(10):319. doi: 10.1007/s00284-023-03437-3.
The 3p21.31 locus has been associated with severe COVID-19 prognosis in GWAS studies. Here, we evaluated whether three polymorphisms (LZTFL1 rs10490770, CXCR6 rs2234355 and rs2234358) in the reported locus were associated with the need for mechanical ventilation, hospitalization length and death in 102 COVID-19 hospitalized Brazilian subjects. No genetic association was found with the need for mechanical ventilation and hospitalization length. CXCR6 rs2234355 was associated with mortality under the codominance model, with carriers of the A/A genotype having a greater chance of death than A/G (OR: 10.5; 95% CI: 1.55-70.76). Our results further suggest that the CXCR6 genetic variant contributes to COVID-19 outcomes.
3p21.31 基因座与 GWAS 研究中严重 COVID-19 的预后有关。在这里，我们评估了该报告基因座中的三个多态性（LZTFL1 rs10490770、CXCR6 rs2234355 和 rs2234358）是否与 102 名巴西 COVID-19 住院患者需要机械通气、住院时间和死亡有关。未发现与需要机械通气和住院时间相关的遗传关联。在显性模型下，CXCR6 rs2234355 与死亡率相关，A/A 基因型携带者的死亡几率大于 A/G（OR：10.5；95%CI：1.55-70.76）。我们的结果进一步表明，CXCR6 遗传变异与 COVID-19 结局有关。
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