Shelton Janie F, Shastri Anjali J, Ye Chelsea, Weldon Catherine H, Filshtein-Sonmez Teresa, Coker Daniella, Symons Antony, Esparza-Gordillo Jorge, Aslibekyan Stella, Auton Adam
23andMe Inc., Sunnyvale, CA, USA.
Human Genetics-R&D, GSK Medicines Research Centre, Target Sciences-R&D, Stevenage, UK.
Nat Genet. 2021 Jun;53(6):801-808. doi: 10.1038/s41588-021-00854-7. Epub 2021 Apr 22.
COVID-19 presents with a wide range of severity, from asymptomatic in some individuals to fatal in others. Based on a study of 1,051,032 23andMe research participants, we report genetic and nongenetic associations with testing positive for SARS-CoV-2, respiratory symptoms and hospitalization. Using trans-ancestry genome-wide association studies, we identified a strong association between blood type and COVID-19 diagnosis, as well as a gene-rich locus on chromosome 3p21.31 that is more strongly associated with outcome severity. Hospitalization risk factors include advancing age, male sex, obesity, lower socioeconomic status, non-European ancestry and preexisting cardiometabolic conditions. While non-European ancestry was a significant risk factor for hospitalization after adjusting for sociodemographics and preexisting health conditions, we did not find evidence that these two primary genetic associations explain risk differences between populations for severe COVID-19 outcomes.
新冠病毒病（COVID-19）的严重程度范围广泛，从部分个体的无症状感染到另一些个体的死亡。基于对1,051,032名23andMe研究参与者的研究，我们报告了与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）检测呈阳性、呼吸道症状及住院相关的遗传和非遗传关联。通过跨祖先全基因组关联研究，我们确定了血型与COVID-19诊断之间的强关联，以及3号染色体p21.31上一个富含基因的位点，该位点与疾病严重程度的关联更强。住院风险因素包括年龄增长、男性、肥胖、社会经济地位较低、非欧洲血统以及既往存在的心脏代谢疾病。虽然在调整社会人口统计学和既往健康状况后，非欧洲血统是住院的一个重要风险因素，但我们没有发现证据表明这两个主要的遗传关联能够解释不同人群中重症COVID-19结局的风险差异。
