Laboratoire de Recherche en Imagerie et Orthopédie (LIO), Centre de Recherche du CHUM, École de Technologie Supérieure (ÉTS), Viger Tower, 900 St-Denis, Montreal, QC, H2X0A9, Canada.
Univ Lyon, Univ Gustave Eiffel, LBMC UMR_T9406, 69622, Lyon, France.
Sci Rep. 2021 Apr 21;11(1):8594. doi: 10.1038/s41598-021-87978-2.
This study evaluated the association of contact point locations with the knee medial and lateral contact force (F, F) alterations in OA and healthy subjects. A musculoskeletal model of the lower limb with subject-specific tibiofemoral contact point trajectories was used to estimate the F and F in ten healthy and twelve OA subjects during treadmill gait. Regression analyses were performed to evaluate the correlation of the contact point locations, knee adduction moment (KAM), knee flexion moment (KFM), frontal plane alignment, and gait speed with the F and F. Medial contact point locations in the medial-lateral direction showed a poor correlation with the F in OA (R = 0.13, p = 0.01) and healthy (R = 0.24, p = 0.001) subjects. Anterior-posterior location of the contact points also showed a poor correlation with the F of OA subjects (R = 0.32, p < 0.001). Across all subjects, KAM and KFM remained the best predictors of the F and F, respectively (R between 0.62 and 0.69). Results suggest different mechanisms of contact force distribution in OA joints. The variations in the location of the contact points participate partially to explains the F variations in OA subjects together with the KFM and KAM.
本研究评估了接触点位置与 OA 和健康受试者膝关节内侧和外侧接触力（F、F）变化之间的关系。使用下肢肌肉骨骼模型和受试者特异性胫股接触点轨迹来估计在跑步机行走时 10 名健康受试者和 12 名 OA 受试者的 F 和 F。进行回归分析以评估接触点位置、膝内收力矩（KAM）、膝屈曲力矩（KFM）、额状面排列和步态速度与 F 和 F 的相关性。OA（R=0.13，p=0.01）和健康（R=0.24，p=0.001）受试者的内侧接触点在内外方向上的位置与 F 相关性较差。接触点的前后位置也与 OA 受试者的 F 相关性较差（R=0.32，p<0.001）。在所有受试者中，KAM 和 KFM 仍然是 F 和 F 的最佳预测因子（R 介于 0.62 和 0.69 之间）。结果表明，OA 关节的接触力分布机制不同。接触点位置的变化部分解释了 OA 受试者 F 的变化，同时也与 KFM 和 KAM 有关。
