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一种基于激发态分子内质子转移（ESIPT）机制用于光气荧光检测的氨基取代的2-（2'-羟基苯基）苯并咪唑。

An amino-substituted 2-(2'-hydroxyphenyl)benzimidazole for the fluorescent detection of phosgene based on an ESIPT mechanism.

作者信息

Li Zi-Jie, Zhang Wen-Jie, Bi Wen-Zhu, Ma Qiu-Juan, Feng Su-Xiang, Chen Xiao-Lan, Qu Ling-Bo

机构信息

School of Pharmacy, Henan University of Chinese Medicine Zhengzhou 450046 China

Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province Zhengzhou 450046 China.

出版信息

RSC Adv. 2021 Mar 15;11(18):10836-10841. doi: 10.1039/d1ra00811k. eCollection 2021 Mar 10.

DOI:10.1039/d1ra00811k
PMID:35423554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8695812/
Abstract

In this work, an ESIPT-based fluorescence probe, 5'-amino-2-(2'-hydroxyphenyl)benzimidazole (P1), was synthesized and explored for the ratiometric detection of phosgene. Compared to 2-(2'-hydroxyphenyl)benzimidazole (HBI), P1 exhibits high sensitivity (LoD = 5.3 nM) and selectivity toward phosgene with the introduction of the amine group. Furthermore, simple P1 loaded test papers are manufactured and display selective fluorescent detection of phosgene in the gas phase.

摘要

在本工作中，合成了一种基于激发态分子内质子转移（ESIPT）的荧光探针5'-氨基-2-(2'-羟基苯基)苯并咪唑（P1），并对其用于光气的比率检测进行了研究。与2-(2'-羟基苯基)苯并咪唑（HBI）相比，通过引入胺基，P1对光气表现出高灵敏度（检测限 = 5.3 nM）和选择性。此外，制备了简单的负载P1的试纸，并展示了其对气相光气的选择性荧光检测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/75c77585aa3c/d1ra00811k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/36d8fd840421/d1ra00811k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/70af23e01e95/d1ra00811k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/67286f4f75cd/d1ra00811k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/c33de37bf1a1/d1ra00811k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/3d561556ea28/d1ra00811k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/66679e22857c/d1ra00811k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/23c625cd36ca/d1ra00811k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/cec296f11871/d1ra00811k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/75c77585aa3c/d1ra00811k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/36d8fd840421/d1ra00811k-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/70af23e01e95/d1ra00811k-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/67286f4f75cd/d1ra00811k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/c33de37bf1a1/d1ra00811k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/3d561556ea28/d1ra00811k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/66679e22857c/d1ra00811k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/23c625cd36ca/d1ra00811k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/cec296f11871/d1ra00811k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e94/8695812/75c77585aa3c/d1ra00811k-f7.jpg

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