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[具体物质名称1]和[具体物质名称2]的生物活性化合物对人类致病微生物的抗菌活性。

Antimicrobial activity of bioactive compounds of and against human pathogenic microorganisms.

作者信息

Padilla Carlos, Lobos Olga, Poblete-Tapia Patricia, Carrasco-Sánchez Verónica

机构信息

Department of Microbiology, Faculty of Health Sciences, University of Talca, Talca, Chile.

出版信息

Iran J Microbiol. 2021 Feb;13(1):98-103. doi: 10.18502/ijm.v13i1.5498.

DOI:10.18502/ijm.v13i1.5498
PMID:33889368
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8043824/
Abstract

BACKGROUND AND OBJECTIVES

and are medicinal shrubs native to Chile and are popularly known as "Bailahuén". Regularly, this plant is used for liver, digestive and renal affections, as well as colds and the cleaning of infected wounds. The aim of the study was to identify the responsible compounds for the antimicrobial activity of and

MATERIALS AND METHODS

Infusions and ethanolic extracts of and were analysed by thin-layer chromatography bioautography (TLC-B) to determine the compounds responsible for the antimicrobial activity against Gram-positive and Gram-negative bacterial strains and yeasts of Bailahuén. Finally, the minimum inhibitory concentration (MIC) of pure compounds isolated was determinate.

RESULTS

Extract of Bailahuén had activity only against Gram-positive bacterial strains and this activity was associated with aesculetin, 18-acetoxy-cis-cleroda-3,13E-dien-15-oic acid and aromadendrin-7-methyl ether compounds.

CONCLUSION

and have antibacterial capacity on different species of Gram-positive bacteria pathogenic for humans.

摘要

背景与目的

[植物名称1]和[植物名称2]是原产于智利的药用灌木，俗称“Bailahuén”。这种植物常用于治疗肝脏、消化系统和肾脏疾病，以及感冒和清洁感染伤口。本研究的目的是确定[植物名称1]和[植物名称2]抗菌活性的相关化合物。

材料与方法

采用薄层色谱生物自显影法（TLC-B）分析[植物名称1]和[植物名称2]的浸剂和乙醇提取物，以确定对Bailahuén的革兰氏阳性和革兰氏阴性细菌菌株及酵母具有抗菌活性的化合物。最后，测定分离出的纯化合物的最低抑菌浓度（MIC）。

结果

Bailahuén提取物仅对革兰氏阳性细菌菌株有活性，且该活性与七叶亭、18-乙酰氧基-顺式-克罗烷-3,13E-二烯-15-酸和香豆素-7-甲醚化合物有关。

结论

[植物名称1]和[植物名称2]对人类致病性革兰氏阳性细菌的不同物种具有抗菌能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/e1f0bf50edbc/IJM-13-98-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/e4d25a82c667/IJM-13-98-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/11d1d4ba428f/IJM-13-98-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/f0782ba5fe12/IJM-13-98-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/e1f0bf50edbc/IJM-13-98-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/e4d25a82c667/IJM-13-98-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/11d1d4ba428f/IJM-13-98-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/f0782ba5fe12/IJM-13-98-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ed6/8043824/e1f0bf50edbc/IJM-13-98-g004.jpg

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