Zrelovs Nikita, Ustinova Monta, Silamikelis Ivars, Birzniece Liga, Megnis Kaspars, Rovite Vita, Freimane Lauma, Silamikele Laila, Ansone Laura, Pjalkovskis Janis, Fridmanis Davids, Vilne Baiba, Priedite Marta, Caica Anastasija, Gavars Mikus, Perminov Dmitry, Storozenko Jelena, Savicka Oksana, Dimina Elina, Dumpis Uga, Klovins Janis
Latvian Biomedical Research and Study Centre, Riga, Latvia.
Riga Stradins University, Riga, Latvia.
Front Med (Lausanne). 2021 Apr 6;8:626000. doi: 10.3389/fmed.2021.626000. eCollection 2021.
Remaining a major healthcare concern with nearly 29 million confirmed cases worldwide at the time of writing, novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused more than 920 thousand deaths since its outbreak in China, December 2019. First case of a person testing positive for SARS-CoV-2 infection within the territory of the Republic of Latvia was registered on 2nd of March 2020, 9 days prior to the pandemic declaration by WHO. Since then, more than 277,000 tests were carried out confirming a total of 1,464 cases of coronavirus disease 2019 (COVID-19) in the country as of 12th of September 2020. Rapidly reacting to the spread of the infection, an ongoing sequencing campaign was started mid-March in collaboration with the local testing laboratories, with an ultimate goal in sequencing as much local viral isolates as possible, resulting in first full-length SARS-CoV-2 isolate genome sequences from the Baltics region being made publicly available in early April. With 133 viral isolates representing ~9.1% of the total COVID-19 cases during the "first coronavirus wave" in the country (early March, 2020-mid-September, 2020) being completely sequenced as of today, here, we provide a first report on the genetic diversity of Latvian SARS-CoV-2 isolates.
新型严重急性呼吸综合征冠状病毒2（SARS-CoV-2）仍是一个重大的医疗保健问题，在撰写本文时，全球确诊病例近2900万例。自2019年12月在中国爆发以来，SARS-CoV-2已导致超过92万人死亡。拉脱维亚共和国境内第一例SARS-CoV-2感染检测呈阳性的病例于2020年3月2日登记，比世界卫生组织宣布大流行提前9天。从那时起，截至2020年9月12日，该国共进行了超过27.7万次检测，确认了1464例2019冠状病毒病（COVID-19）病例。为了迅速应对感染的传播，3月中旬与当地检测实验室合作启动了一项正在进行的测序活动，最终目标是对尽可能多的本地病毒分离株进行测序，结果在4月初首次公开了波罗的海地区全长SARS-CoV-2分离株基因组序列。截至今天，该国“第一波冠状病毒”期间（2020年3月初至2020年9月中旬），共有133株病毒分离株（占COVID-19病例总数的约9.1%）被完全测序，在此，我们首次报告拉脱维亚SARS-CoV-2分离株的遗传多样性。
