Neukamm Judith, Peltzer Alexander, Nieselt Kay
Institute of Evolutionary Medicine, University of Zurich, 8057 Zurich, Switzerland.
Institute for Bioinformatics and Medical Informatics, University of Tübingen, 72076 Tübingen, Germany.
Bioinformatics. 2021 Oct 25;37(20):3652-3653. doi: 10.1093/bioinformatics/btab190.
In ancient DNA research, the authentication of ancient samples based on specific features remains a crucial step in data analysis. Because of this central importance, researchers lacking deeper programming knowledge should be able to run a basic damage authentication analysis. Such software should be user-friendly and easy to integrate into an analysis pipeline.
DamageProfiler is a Java-based, stand-alone software to determine damage patterns in ancient DNA. The results are provided in various file formats and plots for further processing. DamageProfiler has an intuitive graphical as well as command line interface that allows the tool to be easily embedded into an analysis pipeline.
All of the source code is freely available on GitHub (https://github.com/Integrative-Transcriptomics/DamageProfiler).
Supplementary data are available at Bioinformatics online.
在古DNA研究中，基于特定特征对古代样本进行鉴定仍然是数据分析中的关键步骤。由于这一核心重要性，缺乏深入编程知识的研究人员应该能够运行基本的损伤鉴定分析。此类软件应便于用户使用，并易于集成到分析流程中。
DamageProfiler是一款基于Java的独立软件，用于确定古DNA中的损伤模式。结果以各种文件格式和图表形式提供，以便进一步处理。DamageProfiler具有直观的图形界面和命令行界面，使该工具能够轻松嵌入分析流程。
所有源代码均可在GitHub（https://github.com/Integrative-Transcriptomics/DamageProfiler）上免费获取。
补充数据可在《生物信息学》在线版获取。
