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疫苗接种的伦理:是否应使用能力衡量标准来为 SARS-CoV-2 疫苗接种策略提供信息?

Ethics of vaccination: Should capability measures be used to inform SARS-CoV-2 vaccination strategies?

机构信息

Barts Health NHS Trust, London, UK.

出版信息

Br J Clin Pharmacol. 2022 Jan;88(1):47-55. doi: 10.1111/bcp.14875. Epub 2021 May 7.

Abstract

Proposals for SARS-CoV-2 virus vaccination priorities in the UK and in many other countries are heavily influenced by epidemiological models, which use outcome measures such as deaths or hospitalisation. Limiting the values under consideration to those attributable to the direct effects of infection has the advantage of simplifying the models and the process of decision-making. However, the consequences of the pandemic extend beyond outcomes directly attributable to SARS-CoV-2 infection, and include restrictions on educational and work opportunities, access to services, recreational activities, affiliations and relationships with others, freedom of movement (including escaping abusive relationships), and other determinants of human experience. Capability theory gives emphasis to the freedoms that individuals have to express themselves (in doings and beings). Restrictions on freedoms restrict our capabilities. Capability theory has been used to provide a framework for the evaluation and comparison of international development approaches and in the evaluation of public health policy. There is a clustering of disadvantages associated with this pandemic that adds to pre-existing inequalities. Much of the disadvantage engendered in the SARS-CoV-2 pandemic is left out when public health policy is based on a limited range of metrics. Acknowledging the impact of policy across the range of human freedoms at both a national and international level has the potential to improve policy, facilitate the mitigation of direct and indirect adverse consequences, and improve public confidence and the effectiveness of vaccine deployment strategies.

摘要

在英国和许多其他国家,SARS-CoV-2 病毒疫苗接种优先级的建议受到流行病学模型的严重影响,这些模型使用死亡率或住院率等结果指标。将考虑的数值限制在仅归因于感染的直接影响具有简化模型和决策过程的优势。然而,大流行的后果超出了直接归因于 SARS-CoV-2 感染的结果,包括对教育和工作机会、获得服务、娱乐活动、附属关系和与他人的关系、行动自由(包括逃避虐待关系)以及其他决定人类体验的因素的限制。能力理论强调个人表达自己的自由(行为和存在)。对自由的限制限制了我们的能力。能力理论已被用于为国际发展方法的评估和比较以及公共卫生政策的评估提供框架。与这种大流行相关的不利因素集中在一起,加剧了先前存在的不平等。当公共卫生政策基于有限的指标范围时,大流行引发的大部分不利因素都被排除在外。在国家和国际层面上承认政策对人类自由的各个方面的影响,有可能改善政策,减轻直接和间接不利后果,并提高公众信心和疫苗部署策略的有效性。

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[Technical guidelines for seasonal influenza vaccination in China (2021-2022)].《中国季节性流感疫苗接种技术指南(2021—2022年)》
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本文引用的文献

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Ethical allocation of future COVID-19 vaccines.未来新冠疫苗的伦理分配
J Med Ethics. 2020 Dec 17. doi: 10.1136/medethics-2020-106850.

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