Belfort Ilka Kassandra Pereira, Cunha Ana Paula Almeida, Mendes Francisco Pedro Belfort, Galvão-Moreira Leonardo Victor, Lemos Renata Gaspar, de Lima Costa Lucas Henrique, Monteiro Pablo, Ferreira Mariele Borges, Dos Santos Gerusinete Rodrigues Bastos, Costa Joyce Leal, de Sá Ferreira Alice, Brito Luiz Gustavo Oliveira, Brito Luciane Maria Oliveira, Vidal Flávia Castello Branco, Monteiro Sally Cristina Moutinho
Doctoral Program in Biotechnology - Northeast Biotechnology Network (RENORBIO), Federal University of Maranhão (UFMA), Rua 4 Quadra 9 Casa 3 Residencial Primavera, São Luis, MA, 65052-850, Brazil.
Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís, MA, Brazil.
BMC Womens Health. 2021 Apr 23;21(1):174. doi: 10.1186/s12905-021-01320-6.
Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections are the most common sexually transmitted infections (STIs) globally. The latter has contributed to a variety of adverse outcomes for both sexes. Moreover, in Brazil, epidemiological studies on patients with STIs are limited. Therefore, this study aimed to determine the prevalence of TV and its association with HPV in women undergoing cervical cancer screening.
Women with a normal cervix were recruited from a community-based cervical cancer screening program. Gynecological examinations were conducted, and questionnaires were provided. Vaginal canal and uterine cervix samples were collected for cytological examinations (reported using the 2001 Bethesda System) and tested for the presence of TV and HPV DNA.
In total, 562 women who attended public primary healthcare were included in the study. The T. vaginalis was present in 19.0% (107) and HPV DNA was present in 46.8% (263) of women. Among the women of TV 73.8% (79) had a co-infection with HPV (p = 0.001).
We concluded that a TV infection is associated with an HPV infection of the cervix as well as with the cervical cytological abnormalities. Further studies could reveal the mechanisms by which these two organisms interact at the cellular level, with control for shared behavioral risk factors.
人乳头瘤病毒（HPV）和阴道毛滴虫（TV）感染是全球最常见的性传播感染（STIs）。后者对两性均造成了多种不良后果。此外，在巴西，关于性传播感染患者的流行病学研究有限。因此，本研究旨在确定接受宫颈癌筛查的女性中TV的患病率及其与HPV的关联。
从一项基于社区的宫颈癌筛查项目中招募宫颈正常的女性。进行妇科检查并提供问卷。收集阴道和子宫颈样本进行细胞学检查（使用2001年贝塞斯达系统报告），并检测TV和HPV DNA的存在情况。
本研究共纳入562名到公共初级医疗保健机构就诊的女性。19.0%（107名）的女性存在阴道毛滴虫，46.8%（263名）的女性存在HPV DNA。在感染TV的女性中，73.8%（79名）同时感染了HPV（p = 0.001）。
我们得出结论，TV感染与宫颈HPV感染以及宫颈细胞学异常有关。进一步的研究可以揭示这两种病原体在细胞水平上相互作用的机制，并控制共同的行为风险因素。
