Public Health England - Porton, National Infections Service, Porton Down, Salisbury, Wiltshire, SP4 0JG, UK.
Sci Rep. 2021 Apr 23;11(1):8810. doi: 10.1038/s41598-021-87872-x.
Rhesus (Macaca mulatta) and cynomolgus (Macaca fasicularis) macaques of distinct genetic origin are understood to vary in susceptibility to Mycobacterium tuberculosis, and therefore differences in their immune systems may account for the differences in disease control. Monocyte:lymphocyte (M:L) ratio has been identified as a risk factor for M. tuberculosis infection and is known to vary between macaque species. We aimed to characterise the constituent monocyte and lymphocyte populations between macaque species, and profile other major immune cell subsets including: CD4 and CD8 T-cells, NK-cells, B-cells, monocyte subsets and myeloid dendritic cells. We found immune cell subsets to vary significantly between macaque species. Frequencies of CD4 and CD8 T-cells and the CD4:CD8 ratio showed significant separation between species, while myeloid dendritic cells best associated macaque populations by M. tuberculosis susceptibility. A more comprehensive understanding of the immune parameters between macaque species may contribute to the identification of new biomarkers and correlates of protection.
恒河猴（Macaca mulatta）和食蟹猴（Macaca fascicularis）是两种具有不同遗传起源的猕猴，它们对结核分枝杆菌的易感性存在差异，因此它们的免疫系统的差异可能是导致疾病控制差异的原因。单核细胞与淋巴细胞比值（M:L 比值）已被确定为结核分枝杆菌感染的危险因素，并且已知在猴种之间存在差异。我们旨在描述猴种之间的单核细胞和淋巴细胞群体特征，并分析其他主要免疫细胞亚群，包括：CD4 和 CD8 T 细胞、NK 细胞、B 细胞、单核细胞亚群和髓样树突状细胞。我们发现免疫细胞亚群在猴种之间存在显著差异。CD4 和 CD8 T 细胞的频率以及 CD4:CD8 比值在种间有明显的分离，而髓样树突状细胞最能通过结核分枝杆菌的易感性来区分猴群。更全面地了解猴种之间的免疫参数可能有助于鉴定新的生物标志物和保护相关性。
