Department of Physiotherapy, University of Malaga, C/Arquitecto Peñalosa, 3, 29071, Málaga, Spain.
Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
Sci Rep. 2021 Apr 23;11(1):8858. doi: 10.1038/s41598-021-88375-5.
Changes in body composition and muscle dysfunction are common in metastatic breast cancer (MBC). Ultrasound imaging (US) offers reliable information about muscle and fat tissue architecture (thickness) and quality (echo-intensity). This study aimed to analyze the responsiveness of thickness and echo-intensity and its possible relationship with functional and patient reported-outcomes (PRO) in MBC patients after an exercise intervention. A prospective study was conducted in 2019. A 12-week exercise program was performed, including aerobic exercise and strength training. Measurements were made at baseline and after intervention. Thickness and echo-intensity were obtained from the quadriceps and biceps brachii and brachialis (BB). Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means before and after the intervention (p = 0.05; 95% CI). Data from 13 MBC patients showed that some US muscle variables had significant differences after intervention. Best correlations were found between the quality of life questionnaire (QLQ-BR23) PRO and variables from BB muscle thickness in contraction (r = 0.61, p < 0.01), and Non-contraction (r = 0.55, p < 0.01). BB Muscle Non-contraction Thickness also explained 70% of QLQ-BR23 variance. In conclusion, muscle architecture biomarkers showed great responsiveness and are correlated with PRO after an exercise intervention in MBC patients.
身体成分和肌肉功能障碍在转移性乳腺癌（MBC）中很常见。超声成像（US）可提供有关肌肉和脂肪组织结构（厚度）和质量（回声强度）的可靠信息。本研究旨在分析厚度和回声强度的反应性及其与 MBC 患者运动干预后的功能和患者报告的结果（PRO）之间的可能关系。
2019 年进行了一项前瞻性研究。进行了为期 12 周的运动计划，包括有氧运动和力量训练。在基线和干预后进行测量。从股四头肌和肱二头肌和肱肌（BB）获得厚度和回声强度。使用 T 检验对干预前后均值差异进行参数检验（p=0.05；95%CI），计算均值差异。
13 例 MBC 患者的数据显示，一些 US 肌肉变量在干预后有显著差异。在收缩（r=0.61，p<0.01）和非收缩（r=0.55，p<0.01）时，与生活质量问卷（QLQ-BR23）PRO 的相关性最好。BB 肌肉非收缩厚度也解释了 QLQ-BR23 方差的 70%。
总之，肌肉结构生物标志物在 MBC 患者的运动干预后表现出很大的反应性，并且与 PRO 相关。
