Department of Physical Education and Sport Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Department of Midwifery, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Phytother Res. 2021 Sep;35(9):4898-4912. doi: 10.1002/ptr.7120. Epub 2021 Apr 28.
This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to determine the effects of grapes and grape products on inflammation and oxidative stress among adults. PubMed, Scopus, ISI Web of Science, and Cochrane Library databases were searched up to July 2020 to identify RCTs investigating the effects of grape and grape products on inflammatory and oxidative stress markers. Weighted mean differences (WMD) were pooled using a random-effects model. Of the 8,962 identified studies, 24 RCTs (27 arms) were included in the statistical analysis. Grape products significantly reduced serum C-reactive protein (CRP) levels (WMD: -0.35 mg/L; 95% CI: -0.62, -0.09, p = .008), but they had no significant effect on serum tumor necrosis factor-alpha (TNF-α) (WMD = -1.08 pg/ml; 95% CI: -2.29, 0.11, p = .07), interleukin-6 (IL-6) (WMD = 0.13 pg/ml; 95% CI: -0.35, 0.60, p = .60), total antioxidant capacity (TAC) (WMD = 0.15; 95% CI: -0.35, 0.65, p = .54), or malondialdehyde (MDA) (WMD = 0.14; 95% CI: -0.64, 0.92, p = .72). The analysis indicated possible decreasing effects of grapes and grape products on CRP, but they might not be able to change IL-6, TNF-α, TAC, and MDA concentrations. Nonetheless, further studies are warranted before definitive conclusions may be reached.
这是一项系统评价和荟萃分析，针对随机对照试验（RCTs），旨在确定葡萄和葡萄产品对成年人炎症和氧化应激的影响。检索了 PubMed、Scopus、ISI Web of Science 和 Cochrane Library 数据库，截至 2020 年 7 月，以确定研究葡萄和葡萄产品对炎症和氧化应激标志物影响的 RCTs。使用随机效应模型汇总加权均数差（WMD）。在确定的 8962 项研究中，有 24 项 RCT（27 个臂）纳入了统计分析。葡萄产品显著降低了血清 C 反应蛋白（CRP）水平（WMD：-0.35mg/L；95%CI：-0.62，-0.09，p=0.008），但对血清肿瘤坏死因子-α（TNF-α）（WMD=-1.08pg/ml；95%CI：-2.29，0.11，p=0.07）、白细胞介素-6（IL-6）（WMD=0.13pg/ml；95%CI：-0.35，0.60，p=0.60）、总抗氧化能力（TAC）（WMD=0.15；95%CI：-0.35，0.65，p=0.54）或丙二醛（MDA）（WMD=0.14；95%CI：-0.64，0.92，p=0.72）无显著影响。分析表明，葡萄和葡萄产品可能对 CRP 有降低作用，但可能无法改变 IL-6、TNF-α、TAC 和 MDA 浓度。然而，在得出明确结论之前，还需要进一步的研究。
