Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, China.
School of Chemistry and Chemical Engineering, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
Angew Chem Int Ed Engl. 2021 Jun 25;60(27):15013-15019. doi: 10.1002/anie.202102169. Epub 2021 Jun 1.
Developing smart material systems for performing different tasks in diverse environments remains challenging. Here, we show that by integrating stimuli-responsive soft materials with multi-mode reconfigurable DNA-based chemical reaction circuits (D-CRCs), it can control size change of microgels with multiple reaction pathways and adapt expansion behaviors to meet diverse environments. We first use pH-responsive intramolecular conformational switches for regulating DNA strand displacement reactions (SDRs). The ability to regulate SDRs with tunable pH-dependence allows to build dynamic chemical reaction networks with diverse reaction pathways. We confirm that the designed DNA switching circuits are reconfigurable at different pH and perform different logic operations, and the swelling of DNA switching circuit-integrated microgel systems can be programmably directed by D-CRCs. Our approach provides insight into building smart responsive materials and fabricating autonomous soft robots.
开发可在不同环境中执行不同任务的智能材料系统仍然具有挑战性。在这里，我们展示了通过将响应性软材料与多模式可重构基于 DNA 的化学反应回路 (D-CRC) 集成，可以控制具有多种反应途径的微凝胶的尺寸变化，并使扩展行为适应不同的环境。我们首先使用 pH 响应型分子内构象开关来调节 DNA 链置换反应 (SDR)。通过可调 pH 依赖性调节 SDR 的能力允许构建具有多种反应途径的动态化学反应网络。我们证实，设计的 DNA 开关电路可在不同 pH 值下重新配置，并执行不同的逻辑操作，并且 DNA 开关电路集成的微凝胶系统的溶胀可以由 D-CRC 进行可编程控制。我们的方法为构建智能响应材料和制造自主软机器人提供了思路。
