Pharmacology Department, College of Medicine, Minia University, Egypt.
Biomed Pharmacother. 2021 Jul;139:111626. doi: 10.1016/j.biopha.2021.111626. Epub 2021 Apr 21.
In this manuscript we provide the scientific basis to adopt a novel combination of two widely available nutraceuticals; resveratrol and zinc in management of COVID-19 recommending their administration using a nano-carrier based drug-delivery system. Resveratrol, a well-known antioxidant and anti-inflammatory triphenolic stilbene, is abundant in red grapes, red wine, dark chocolate, and peanut butter. Alternatively, pterostilbene-zinc combination might be also considered without using a nano-carrier. We recommend conducting prompt clinical trials to assess the potential of the suggested combinations as a monotherapy for mild COVID-19 with a potential to prevent its progression to moderate-severe disease for which we recommend their trial as an adjuvant therapy. Furthermore, the suggested combinations might also possess a pharmacotherapeutic potential that exceeds COVID-19 to various inflammatory, immunologic, and oncologic diseases.
在本文中，我们提供了将两种广泛可用的营养保健品（白藜芦醇和锌）组合使用的科学依据，用于管理 COVID-19，建议使用基于纳米载体的药物传递系统进行管理。白藜芦醇是一种众所周知的抗氧化剂和抗炎性三酚芪，存在于红葡萄、红酒、黑巧克力和花生酱中。或者，可以不使用纳米载体而使用紫檀芪-锌组合。我们建议尽快开展临床试验，评估所建议组合作为轻度 COVID-19 单一疗法的潜力，以及预防其进展为中重度疾病的潜力，对于后者，我们建议将其作为辅助疗法进行试验。此外，所建议的组合可能还具有超出 COVID-19 的药物治疗潜力，可用于各种炎症、免疫和肿瘤疾病。
