Yoshioka H, Fujiwara K, Ishimura K, Iino S, Nishimura O, Tominaga M, Kusunoki T, Nishikawa H
Department of Pediatrics, Kyoto Prefectural University of Medicine, Japan.
Brain Dev. 1988;10(2):88-91. doi: 10.1016/s0387-7604(88)80077-9.
Brain energy metabolism was studied in vivo by means of 31P-NMR spectroscopy in newborn mice during and after 20-minutes exposure to either pure carbon dioxide gas or nitrogen gas. In the N2 group, the brain ATP concentration remained almost normal throughout the experiment, while it showed a 30% reduction in the CO2 group. The brain concentration of phosphocreatine dropped to about 20% of the control value during the asphyxia in both groups, and its recovery was significantly delayed in the CO2 group compared to in the N2 group. Tissue acidosis and Pi accumulation were more remarkable and prolonged in the CO2 group.
通过31P-NMR光谱法在新生小鼠体内研究了脑能量代谢，这些小鼠在暴露于纯二氧化碳气体或氮气20分钟期间及之后进行观察。在氮气组中，整个实验过程中脑ATP浓度几乎保持正常，而在二氧化碳组中则显示出30%的降低。两组在窒息期间磷酸肌酸的脑浓度均降至对照值的约20%，并且与氮气组相比，二氧化碳组中其恢复明显延迟。二氧化碳组中的组织酸中毒和无机磷酸盐积累更为显著且持续时间更长。
