Moorcraft J, Bolas N M, Ives N K, Ouwerkerk R, Smyth J, Rajagopalan B, Hope P L, Radda G K
Department of Paediatrics, John Radcliffe Hospital, Oxford.
Arch Dis Child. 1991 Oct;66(10 Spec No):1119-23. doi: 10.1136/adc.66.10_spec_no.1119.
Twelve normal and 32 asphyxiated neonates were studied using global and depth resolved phosphorus magnetic resonance spectroscopy (31PMRS). Eight of the asphyxiated group died or survived with major neurodevelopmental abnormalities. A global phosphocreatinine/inorganic phosphate (PCr/Pi) ratio below the range of values from normal infants predicted adverse outcome after asphyxia with a positive predictive value of 64%, sensitivity 88%, and specificity 83%. Corresponding values for global inorganic orthophosphate/adenosine triphosphate (Pi/ATP) ratios were positive predictive value 88%, sensitivity 96%, and specificity 88%. Spatially localised MRS data, obtained using phase modulated rotating frame imaging, showed cerebral energy metabolism to be more abnormal in deep than superficial regions after birth asphyxia. However, in this population of full term infants none of the regional metabolite concentrations were superior to global data for prediction of outcome.
使用整体及深度分辨磷磁共振波谱（31PMRS）对12名正常新生儿和32名窒息新生儿进行了研究。窒息组中有8名死亡或存活但伴有严重神经发育异常。窒息后，整体磷酸肌酸/无机磷酸盐（PCr/Pi）比值低于正常婴儿值范围可预测不良预后，其阳性预测值为64%，敏感性为88%，特异性为83%。整体无机正磷酸盐/三磷酸腺苷（Pi/ATP）比值的相应值为阳性预测值88%，敏感性96%，特异性88%。使用相位调制旋转框架成像获得的空间定位MRS数据显示，出生窒息后深部区域的脑能量代谢比浅表区域更异常。然而，在这群足月婴儿中，没有任何区域代谢物浓度在预测预后方面优于整体数据。
