Hope P L, Costello A M, Cady E B, Delpy D T, Tofts P S, Chu A, Hamilton P A, Reynolds E O, Wilkie D R
Lancet. 1984 Aug 18;2(8399):366-70. doi: 10.1016/s0140-6736(84)90539-7.
Phosphorus (31P) nuclear magnetic resonance spectroscopy was used to study intracellular metabolism in the brains of 6 normal newborn infants and 10 infants who had been asphyxiated during delivery. In the normal infants spectral peaks mainly attributable to adenosine triphosphate, phosphocreatine (PCr), phosphodiesters plus phospholipids, and inorganic orthophosphate (Pi) were always detected, together with an additional large peak in the phosphomonoester region indicating the presence of a metabolite or metabolites (probably largely phosphoethanolamine) which may be involved in rapid growth of the brain. In the asphyxiated infants, data obtained on the first day of life showed no differences from those in normal infants, but by the second to ninth days inverse changes in the concentrations of PCr and Pi had caused a significant reduction in PCr/Pi. This latency suggest the possibility of effective early treatment before irreversible metabolic damage sets in. Mean intracellular pH when PCr/Pi was minimal was 7.17 +/- 0.10. Values for PCr/Pi below 0.80 were associated with a very bad prognosis for survival and early neuro-developmental outcome.
采用磷（³¹P）核磁共振波谱法研究了6名正常新生儿和10名分娩时窒息婴儿大脑中的细胞内代谢情况。在正常婴儿中，总能检测到主要归因于三磷酸腺苷、磷酸肌酸（PCr）、磷酸二酯加磷脂以及无机正磷酸盐（Pi）的光谱峰，同时在磷酸单酯区域还有一个额外的大峰，表明存在一种或多种代谢物（可能主要是磷酸乙醇胺），其可能与大脑的快速生长有关。在窒息婴儿中，出生第一天获得的数据与正常婴儿无异，但到第二天至第九天，PCr和Pi浓度的反向变化导致PCr/Pi显著降低。这种延迟表明在不可逆的代谢损伤发生之前进行有效早期治疗的可能性。PCr/Pi最小时的平均细胞内pH值为7.17±0.10。PCr/Pi值低于0.80与生存及早期神经发育结局的预后极差相关。
