Avila-Nava Azalia, Cortes-Telles Arturo, Torres-Erazo Darwin, López-Romero Stephanie, Chim Aké Rodolfo, Gutiérrez Solis Ana Ligia
Regional High Speciality Hospital of the Yucatan Peninsula (HRAEPY), Merida, Yucatan, Mexico.
Regional High Speciality Hospital of the Yucatan Peninsula (HRAEPY), Merida, Yucatan, Mexico.
Cytokine. 2021 Jul;143:155543. doi: 10.1016/j.cyto.2021.155543. Epub 2021 Apr 17.
The first case of SARS-CoV-2 in Mexico was reported in February 2020, since then, high rates of mortality due to COVID-19 have been found. Cytokine storm is linked to the severity and decreasing the survival among infected patients by COVID-19. The serum levels of Interleukin 6 (IL-6) have been correlated to mortality in COVID-19 cases and could be used as indicator of mortality in COVID-19 cases. The aim of this study was to determine levels of IL-6 and assess its usefulness as indicator of mortality among COVID-19 patients from Mexico.
A cohort study among 38 adults (28 men, 10 women) was carried out in the Regional High Specialty Hospital of the Yucatan Peninsula in Merida, Yucatan, Mexico. Demographic and clinical biochemistry data were collected. The serum levels of IL-6 were measured in each patient by specific immunoassays.
High frequency of mortality (36.84%) was found in the sample. The average age of individuals that non-survive was significantly higher (59.71 ± 13.83 years) than the survival group (43.29 ± 11.80 years). Serum levels of IL-6 were significantly higher in patients that did not survive. A correlation between IL-6 levels with lymphocyte count, LDH, CRP and procaciltonin was found. The optimal cutoff value of IL-6 was 30.95 pg/mL with high sensitivity and specificity.
Our findings demonstrate that level of IL-6 is an indicator of mortality among hospitalized COVID-19 patients in Mexico.
2020年2月墨西哥报告了首例新型冠状病毒肺炎（SARS-CoV-2）病例，自那时起，发现因新型冠状病毒病（COVID-19）导致的死亡率很高。细胞因子风暴与COVID-19感染患者的病情严重程度相关，并降低其生存率。白细胞介素6（IL-6）的血清水平与COVID-19病例的死亡率相关，可作为COVID-19病例死亡率的指标。本研究的目的是确定墨西哥COVID-19患者的IL-6水平，并评估其作为死亡率指标的实用性。
在墨西哥尤卡坦州梅里达市尤卡坦半岛地区高级专科医院对38名成年人（28名男性，10名女性）进行了一项队列研究。收集了人口统计学和临床生化数据。通过特异性免疫测定法测量每位患者的IL-6血清水平。
样本中发现高死亡率（36.84%）。未存活个体的平均年龄（59.71±13.83岁）显著高于存活组（43.29±11.80岁）。未存活患者的IL-6血清水平显著更高。发现IL-6水平与淋巴细胞计数、乳酸脱氢酶、C反应蛋白和降钙素原之间存在相关性。IL-6的最佳截断值为30.95 pg/mL，具有高敏感性和特异性。
我们的研究结果表明，IL-6水平是墨西哥住院COVID-19患者死亡率的一个指标。
