用于在亚细胞分辨率下与神经元连接的高度集成CMOS微系统。
Highly integrated CMOS microsystems to interface with neurons at subcellular resolution.
作者信息
Hierlemann Andreas, Müller Jan, Bakkum Douglas, Franke Felix
机构信息
ETH Zurich, Department of Biosystems Science and Engineering CH-4058, Basel, Switzerland.
出版信息
Tech Dig Int Electron Devices Meet. 2015;2015:13.2.1-13.2.4. doi: 10.1109/IEDM.2015.7409688. Epub 2016 Feb 18.
Abstract
CMOS high-density transducer arrays enable fundamentally new neuroscientific insights through, e.g., facilitating investigation of axonal signaling characteristics, with the "axonal" side of neuronal activity being largely inaccessible to established methods. They also enable high-throughput monitoring of potentially all action potentials in a larger neuronal network (> 1000 neurons) over extended time to see developmental effects or effects of disturbances. Applications include research in neural diseases and pharmacology.
摘要
互补金属氧化物半导体（CMOS）高密度换能器阵列能够带来全新的神经科学见解，例如，通过促进对轴突信号特征的研究，而传统方法在很大程度上无法触及神经元活动的“轴突”方面。它们还能够在较长时间内对更大的神经元网络（>1000个神经元）中潜在的所有动作电位进行高通量监测，以观察发育效应或干扰效应。应用领域包括神经疾病研究和药理学研究。
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