New approaches for CMOS-based devices for large-scale neural recording.

Extracellular, large scale in vivo recording of neural activity is mandatory for elucidating the interaction of neurons within large neural networks at the level of their single unit activity. Technological achievements in MEMS-based multichannel electrode arrays offer electrophysiological recording capabilities that go far beyond those of classical wire electrodes. Despite their impressive channel counts, recording systems with modest interconnection overhead have been demonstrated thanks to the hybrid integration of CMOS circuitry for signal preprocessing and data handling. The number of addressable channels is increased even further by a switch matrix for electrode selection co-integrated along the slender probe shafts. When realized by IC fabrication technologies, these probes offer highest recording site densities along the entire shaft length.