Huang Lichuang, Hu Shaoqi, Shao Meiyu, Wu Xin, Zhang Jida, Cao Gang
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.
College of Basic Medical Science, Institute of Basic Research in Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Front Pharmacol. 2021 Apr 9;12:639009. doi: 10.3389/fphar.2021.639009. eCollection 2021.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that leads to cartilage destruction and bone erosion. In-depth exploration of the pathogenesis of RA and the development of effective therapeutic drugs are of important clinical and social value. Herein, we explored the medicinal value of Cornus officinalis Sieb. and Paeonia lactiflora Pall. in RA treatment using a rat model of collagen-induced arthritis (CIA). We compared the therapeutic effect of Cornus officinalis and Paeonia lactiflora with that of their main active compounds, ursolic acid and paeoniflorin, respectively. We demonstrated that the combination of Cornus officinalis and Paeonia lactiflora effectively inhibited the release of factors associated with oxidative stress and inflammation during RA, therein ameliorating the symptoms and suppressing the progression of RA. We further showed that the underlying mechanisms may be related to the regulation of apoptosis in synovial tissues, and we investigated the potential involvement of AMPK-mediated mitochondrial dynamics in the therapeutic action of the two drugs and their active components.
类风湿关节炎（RA）是一种导致软骨破坏和骨质侵蚀的慢性自身免疫性疾病。深入探究RA的发病机制并开发有效的治疗药物具有重要的临床和社会价值。在此，我们使用胶原诱导性关节炎（CIA）大鼠模型探究了山茱萸和白芍在RA治疗中的药用价值。我们分别比较了山茱萸和白芍与其主要活性化合物熊果酸和芍药苷的治疗效果。我们证明，山茱萸和白芍的组合有效抑制了RA期间与氧化应激和炎症相关的因子释放，从而改善症状并抑制RA的进展。我们进一步表明，潜在机制可能与滑膜组织中细胞凋亡的调节有关，并且我们研究了AMPK介导的线粒体动力学在这两种药物及其活性成分治疗作用中的潜在参与情况。
