Department of Dermatology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Front Immunol. 2021 Apr 9;12:663102. doi: 10.3389/fimmu.2021.663102. eCollection 2021.
Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further formation of homodimers, heteromers, and receptor mosaic. Increasing evidence suggests that the immune system can be affected by the nervous system and neurotransmitters, such as dopamine. Recently, the role of the DA receptor in inflammation has been widely studied, mainly focusing on NLRP3 inflammasome, NF-κB pathway, and immune cells. This article provides a brief review of the structures, functions, and signaling pathways of DA receptors and their relationships with inflammation. With detailed descriptions of their roles in Parkinson disease, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis, this article provides a theoretical basis for drug development targeting DA receptors in inflammatory diseases.
多巴胺（DA）受体是一种重要的 G 蛋白偶联受体，可分为 D1 样（D1 和 D5）和 D2 样（D2、D3 和 D4）受体家族，进一步形成同源二聚体、异源二聚体和受体镶嵌。越来越多的证据表明，免疫系统可以受到神经递质如多巴胺的影响。最近，DA 受体在炎症中的作用得到了广泛研究，主要集中在 NLRP3 炎性体、NF-κB 途径和免疫细胞上。本文简要综述了 DA 受体的结构、功能和信号通路及其与炎症的关系。详细描述了它们在帕金森病、炎症性肠病、类风湿关节炎、系统性红斑狼疮和多发性硬化症中的作用，为靶向炎症性疾病中 DA 受体的药物开发提供了理论基础。
