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产前和产后母亲的抑郁症状及轨迹与儿童24个月内住院情况:来自2015年佩洛塔斯(巴西)出生队列研究的结果

Antenatal and Postnatal Maternal Depressive Symptoms and Trajectories and Child Hospitalization up to 24 Months of Life: Findings From the 2015 Pelotas (Brazil) Birth Cohort Study.

作者信息

Jacques Nadège, Mesenburg Marilia Arndt, Murray Joseph, Bertoldi Andréa Dâmaso, Domingues Marlos Rodrigues, Stein Alan, Silveira Mariangela Freitas

机构信息

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, Brazil.

出版信息

J Pediatr X. 2021 Spring;6:100065. doi: 10.1016/j.ympdx.2021.100065.

Abstract

OBJECTIVE

To examine the association between antenatal and postnatal maternal depression symptoms, and child hospitalization during the first 2 years of life in the 2015 Pelotas Birth Cohort Study.

STUDY DESIGN

This is an observational study. Maternal depressive symptoms of 4275 mothers were measured using the Edinburgh Postnatal Depression Scale. Hospitalization of the child for any reason was assessed using maternal report. Bivariate analysis and multivariate Poisson regressions were used to assess the association between maternal depressive symptoms and child hospitalization.

RESULTS

Compared with children of mothers with low depressive symptoms, children whose mothers experienced significant antenatal depressive symptoms were 1.74 (95% CI, 1.16-2.60) times more likely to be hospitalized by 3 months of age, and 2.14 (95% CI, 1.46-3.14) times more likely up to 24 months. For children whose mothers experienced severe postnatal depressive symptoms at 3 months, the risks for hospitalization by age 12 months were 1.84 (95% CI, 1.39-2.45) higher than children whose mothers had low depressive symptoms. There was an increased risk of hospitalization for children according to the severity of depressive trajectories across time.

CONCLUSIONS

Maternal depressive symptoms are a risk factor for hospitalization in children up to 2 years of age, and this risk increases with increased severity of depression. These results have public health relevance for decreasing the risk factors in mothers that can lead to hospitalization in children.

摘要

目的

在2015年佩洛塔斯出生队列研究中,探讨产前和产后母亲抑郁症状与儿童出生后头两年住院情况之间的关联。

研究设计

这是一项观察性研究。使用爱丁堡产后抑郁量表对4275名母亲的抑郁症状进行测量。通过母亲报告评估儿童因任何原因的住院情况。采用双变量分析和多变量泊松回归来评估母亲抑郁症状与儿童住院之间的关联。

结果

与母亲抑郁症状较轻的儿童相比,母亲在产前有明显抑郁症状的儿童在3个月大时住院的可能性高1.74倍(95%置信区间,1.16 - 2.60),到24个月时高2.14倍(95%置信区间,1.46 - 3.14)。对于母亲在3个月时出现严重产后抑郁症状的儿童,到12个月时住院风险比母亲抑郁症状较轻的儿童高1.84倍(95%置信区间,1.39 - 2.45)。根据不同时期抑郁轨迹的严重程度,儿童住院风险增加。

结论

母亲抑郁症状是2岁以下儿童住院的一个风险因素,且这种风险随着抑郁严重程度的增加而升高。这些结果对于降低可能导致儿童住院的母亲相关风险因素具有公共卫生意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9203/10236561/ccd1e029d537/gr1.jpg

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