Lausanne University Hospital, Department of Psychiatry, Prilly, Switzerland.
Université de Bordeaux, Institut des Maladies Neurodégénératives, Bordeaux, France.
Elife. 2021 Apr 26;10:e64993. doi: 10.7554/eLife.64993.
Delineating the decision-making mechanisms underlying choice between drug and nondrug rewards remains a challenge. This study adopts an original approach to probe these mechanisms by comparing response latencies during sampling versus choice trials. While lengthening of latencies during choice is predicted in a deliberative choice model (DCM), the race-like response competition mechanism postulated by the Sequential choice model (SCM) predicts a shortening of latencies during choice compared to sampling. Here, we tested these predictions by conducting a retrospective analysis of cocaine-versus-saccharin choice experiments conducted in our laboratory. We found that rats engage deliberative decision-making mechanisms after limited training, but adopt a SCM-like response selection mechanism after more extended training, while their behavior is presumably habitual. Thus, the DCM and SCM may not be general models of choice, as initially formulated, but could be dynamically engaged to control choice behavior across early and extended training.
阐明药物和非药物奖励之间选择的决策机制仍然是一个挑战。本研究采用一种新颖的方法，通过比较采样与选择试验期间的反应时来探究这些机制。虽然在审慎选择模型 (DCM) 中预测选择期间的潜伏期会延长，但顺序选择模型 (SCM) 提出的类似竞赛的反应选择机制预测选择期间的潜伏期会比采样期间缩短。在这里，我们通过对我们实验室进行的可卡因与蔗糖选择实验进行回顾性分析来检验这些预测。我们发现，大鼠在有限的训练后会采用审慎的决策机制，但在更长时间的训练后会采用类似于 SCM 的反应选择机制，而它们的行为可能是习惯的。因此，DCM 和 SCM 可能不是最初提出的一般选择模型，而是可以在早期和扩展训练中动态参与控制选择行为。
