长期摄入铵对急性铵中毒的保护作用。

Protective effect of long term ammonium ingestion against acute ammonium intoxication.

作者信息

Miñana M D, Felipo V, Grisolía S

机构信息

Instituto de Investigaciones Citológicas de la Caja de Ahorros de Valencia, Centro Asociado del CSIC Amadeo de Saboya, Valencia, Spain.

出版信息

Biochem Biophys Res Commun. 1988 Jun 30;153(3):979-83. doi: 10.1016/s0006-291x(88)81324-x.

DOI:10.1016/s0006-291x(88)81324-x

PMID:3390190

Abstract

Rats were fed for 15 days a diet containing ammonium acetate (20% w/w) and then injected i. p. with ammonium acetate (7 mmol/Kg). Only 1 out of 18 control rats but 9 of 18 rats fed ammonium survived, indicating a protective effect of ammonium ingestion against an acute ammonia challenge. Blood ammonia returned to normal levels sooner in hyperammonemic rats, suggesting more rapid detoxication. In controls, blood urea levels rose immediately reaching a maximum at 15 min, however in hyperammonemic rats urea levels did not change during the first hour, then rose slowly up to 3 hours. These results suggest that in the ammonium fed rats ammonia is initially sequestered and finally eliminated as urea.

摘要

给大鼠喂食含醋酸铵（20% w/w）的饲料15天，然后腹腔注射醋酸铵（7 mmol/Kg）。18只对照大鼠中只有1只存活，但18只喂食醋酸铵的大鼠中有9只存活，表明摄入铵对急性氨攻击有保护作用。高氨血症大鼠的血氨恢复正常水平更快，表明解毒更快。在对照组中，血尿素水平立即升高，在15分钟时达到最大值，然而在高氨血症大鼠中，尿素水平在最初1小时内没有变化，然后在3小时内缓慢上升。这些结果表明，在喂食铵的大鼠中，氨最初被隔离，最终以尿素形式被清除。