熊猴实验性牙周病的纵向研究：微生物群与牙槽骨丧失之间的关系
Longitudinal study of experimentally induced periodontal disease in Macaca arctoides: relationship between microflora and alveolar bone loss.
作者信息
Slots J, Hausmann E
出版信息
Infect Immun. 1979 Feb;23(2):260-9. doi: 10.1128/iai.23.2.260-269.1979.
Abstract
Macaca arctoides monkeys develop periodontal disease, and they harbor a periodontopathic indigenous flora largely similar to that of humans. This study showed that various Haemophilus isolates and H2O2-splitting asaccharolytic Bacteroides melaninogenicus strains constituted major segments of the monkey periodontal microflora. These organisms have not been previously identified among human isolates. Furthermore, the present data revealed that asaccharolytic B. melaninogenicus strains increased in proportion from a few percent to about 66% of the total isolates concomitant with the development of a significant loss of alveolar bone mass. Hence, this study strongly implicates B. melaninogenicus subsp. asaccharolyticus and closely related strains as important pathogens in actively destructive periodontal disease.
摘要
熊猴会患牙周病，并且它们体内存在大量与人类相似的牙周病原性本土菌群。这项研究表明，各种嗜血杆菌分离株以及产H2O2的非糖化产黑色素拟杆菌菌株构成了猴牙周微生物群的主要部分。这些微生物此前尚未在人类分离株中被鉴定出来。此外，目前的数据显示，随着牙槽骨量显著丢失的发展，非糖化产黑色素拟杆菌菌株的比例从总分离株的百分之几增加到约66%。因此，本研究强烈表明非糖化产黑色素拟杆菌亚种以及密切相关的菌株是活动性破坏性牙周病的重要病原体。
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REQUIRED ROLE OF BACTEROIDES MELANINOGENICUS IN MIXED ANAEROBIC INFECTIONS.产黑素拟杆菌在混合厌氧感染中的必需作用
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