大麻中大麻二酚（CBD）的微生物生物转化。

Microbial Biotransformation of Cannabidiol (CBD) from Cannabis sativa.

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.

National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA.

出版信息

Planta Med. 2022 Apr;88(5):389-397. doi: 10.1055/a-1468-3781. Epub 2021 Apr 26.

DOI:10.1055/a-1468-3781

PMID:33902128

Abstract

Microbial biotransformation of cannabidiol was assessed using 31 different microorganisms. Only (ATCC 9628), (ATCC 7195), and (ATCC 22 752) were able to metabolize cannabidiol. (ATCC 9628) yielded five metabolites, namely, 7,4″-dihydroxycannabidiol (1: ), 6,4″-dihydroxycannabidiol (2: ), 6,2″-dihydroxycannabidiol (3: ), 6,3″-dihydroxycannabidiol (4: ), and 6,7,4″-trihydroxycannabidiol (5: ). (ATCC 7195) metabolized cannabidiol to afford six metabolites identified as 7,3″-dihydroxycannabidivarin (6: ), 7-hydroxycannabidivarin-3″-carboxylic acid (7: ), 3″-hydroxycannabidivarin (8: ), 4″-hydroxycannabidiol (9: ), and cannabidivarin-3″-carboxylic acid (10: ) along with compound 1: . Incubation of cannabidiol with (ATCC 22 752) yielded three metabolites, 6,3″-dihyroxycannabidivarin (11: ), 6,3″-dihyroxycannabidivarin (12: ), and compound 6: . All compounds were evaluated for their antimicrobial and antiprotozoal activity.

摘要

采用 31 种不同的微生物评估了大麻二酚的微生物生物转化。只有（ATCC 9628）、（ATCC 7195）和（ATCC 22 752）能够代谢大麻二酚。（ATCC 9628）产生了五种代谢物，分别为 7,4″-二羟基大麻二酚（1: ）、6,4″-二羟基大麻二酚（2: ）、6,2″-二羟基大麻二酚（3: ）、6,3″-二羟基大麻二酚（4: ）和 6,7,4″-三羟基大麻二酚（5: ）。（ATCC 7195）代谢大麻二酚生成了六种代谢物，鉴定为 7,3″-二羟基大麻非醇（6: ）、7-羟基大麻非醇-3″-羧酸（7: ）、3″-羟基大麻非醇（8: ）、4″-羟基大麻二酚（9: ）和大麻非醇-3″-羧酸（10: ）以及化合物 1: 。用（ATCC 22 752）孵育大麻二酚生成了三种代谢物，6,3″-二羟基大麻非醇（11: ）、6,3″-二羟基大麻非醇（12: ）和化合物 6: 。所有化合物均进行了抗菌和抗原生动物活性评估。