Zhonghua Zhong Liu Za Zhi. 2021 Apr 23;43(4):395-404. doi: 10.3760/cma.j.cn112152-20210313-00226.
Thymic tumor is a relatively rare type of thoracic cancer, which is pathologically-classified as thymic epithelial tumors by World Health Organization (WHO), including thymoma and thymic carcinoma. The incidence of thymic epithelial tumors in China is about 4.09 per million, which is slightly higher than that in European and American countries. For surgically-resectable thymic epithelial tumors, complete resection with or without postoperative radiotherapy or chemotherapy is preferred. For advanced unresectable disease, conventional radiotherapy and chemotherapy is the mainstream treatment but lack of standard first-line and second-line regimens. In recent years, targeted drugs and the immune checkpoint inhibitors have gradually exhibited certain therapeutic prospect in this subset of tumor. Since there was no guideline regarding thymic epithelial tumor released in China, Multidisciplinary Committee on Oncology, Chinese Physicians Association analyze, summarize and discuss the relevant research data for the diagnosis, treatment and prognosis of thymic epithelial tumors, and formulate the "Chinese guidelines for clinical diagnosis and treatment of thymic epithelial tumors (2021 Edition)" for clinicians' reference.
胸腺瘤是一种相对罕见的胸段癌症,世界卫生组织(WHO)将其病理分类为胸腺上皮肿瘤,包括胸腺瘤和胸腺癌。中国胸腺上皮肿瘤的发病率约为百万分之4.09,略高于欧美国家。对于可手术切除的胸腺上皮肿瘤,首选完整切除,术后可联合或不联合放疗或化疗。对于不可切除的晚期疾病,传统放疗和化疗是主流治疗方法,但缺乏标准的一线和二线治疗方案。近年来,靶向药物和免疫检查点抑制剂在这一肿瘤亚群中逐渐展现出一定的治疗前景。由于中国尚未发布关于胸腺上皮肿瘤的指南,中国医师协会肿瘤多学科委员会分析、总结并讨论了胸腺上皮肿瘤诊断、治疗及预后的相关研究数据,制定了《中国胸腺上皮肿瘤临床诊疗指南(2021年版)》供临床医生参考。