In vitro testing of an indirect mutagen (cyclophosphamide) with human leukocyte cultures: activation with liver microsomes and use of a dialysis bag.

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作者信息

Madle S, Obe G

出版信息

Mutat Res. 1977 Sep;56(1):101-4. doi: 10.1016/0027-5107(77)90250-0.

DOI:10.1016/0027-5107(77)90250-0

PMID:339073

Abstract

摘要

相似文献

In vitro testing of an indirect mutagen (cyclophosphamide) with human leukocyte cultures: activation with liver microsomes and use of a dialysis bag.

Mutat Res. 1977 Sep;56(1):101-4. doi: 10.1016/0027-5107(77)90250-0.

Testing in vitro of an indirect mutagen (cyclophosphamide) with human leukocyte cultures: Activation by liver perfusion and by incubation with crude liver homogenate.用人白细胞培养物对间接诱变剂（环磷酰胺）进行体外试验：通过肝脏灌注和与粗制肝匀浆孵育实现激活。

Mutat Res. 1978 Aug;54(1):95-9. doi: 10.1016/0165-1161(78)90139-5.

In vitro testing of an indirect mutagen (cyclophosphamide) with human leukocyte cultures. Activation by a non-enzymatic hydroxylation system (Udenfriend system).用人白细胞培养物对间接诱变剂（环磷酰胺）进行体外试验。由非酶促羟基化系统（乌登弗尔德系统）激活。

Mutat Res. 1978 Jan;49(1):149-51. doi: 10.1016/0027-5107(78)90088-x.

A modified host-mediated assay using cultured human lymphoid cells in diffusion chambers in mice and cytogenetic effects of cyclophosphamide.一种改良的宿主介导试验，该试验采用在小鼠扩散室中培养的人淋巴细胞以及环磷酰胺的细胞遗传学效应。

Environ Res. 1977 Apr;13(2):267-77. doi: 10.1016/0013-9351(77)90103-7.

An in vitro metabolic activation assay using liver microsomes in diffusion chambers: induction of sister chromatid exchanges and chromosome aberrations by cyclophosphamide or ifosfamide in cultured human and Chinese hamster cells.在扩散室内使用肝微粒体的体外代谢活化测定法：环磷酰胺或异环磷酰胺在培养的人及中国仓鼠细胞中诱发姐妹染色单体交换和染色体畸变。

Carcinogenesis. 1980 Jan;1(1):37-40. doi: 10.1093/carcin/1.1.37.

Sister chromatid exchange as an assay for genetic damage induced by mutagen-carcinogens. II. In vitro test for compounds requiring metabolic activation.姐妹染色单体交换作为诱变致癌物诱导的遗传损伤的一种检测方法。II. 对需要代谢活化的化合物的体外试验。

Mutat Res. 1976 Dec;41(2-3):343-50. doi: 10.1016/0027-5107(76)90107-x.

In vitro testing of chlorpropamide with human lymphocyte cultures in the presence of liver microsome fraction S9 mix of rats.

Arzneimittelforschung. 1982;32(7):724-6.

Indirect mutagen assay in human lymphocyte in the presence of a metabolic activation system.在代谢活化系统存在的情况下，对人类淋巴细胞进行间接诱变试验。

J Hyg Epidemiol Microbiol Immunol. 1986;30(4):371-6.

The use of rat liver perfusion to detect indirect mutagens/carcinogens in human leukocytes in vitro.

Arzneimittelforschung. 1981;31(5):822-4.

[The role of the microsomal mono-oxygenase system in modifying the effect of mutagens].[微粒体单加氧酶系统在改变诱变剂作用方面的作用]

Vestn Ross Akad Med Nauk. 1993(1):41-6.

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In Vitro. 1980 Apr;16(4):269-76. doi: 10.1007/BF02618331.

Cytogenetical tests on mammalian cells in vitro.哺乳动物细胞体外细胞遗传学试验。

Arch Toxicol. 1980 Nov;46(1-2):61-75. doi: 10.1007/BF00361246.

Methods for analysis of the mutagenicity of indirect mutagens/carcinogens in eukaryotic cells.真核细胞中间接诱变剂/致癌物诱变性的分析方法。

Hum Genet. 1980;56(1):7-20. doi: 10.1007/BF00281566.

Cyclophosphamide-induced in vivo sister chromatid exchanges (SCE) in Mus musculus. III. Quantitative genetic analysis.环磷酰胺诱导小家鼠体内姐妹染色单体交换（SCE）。III. 数量遗传学分析。

Genetics. 1983 Sep;105(1):169-79. doi: 10.1093/genetics/105.1.169.

Possible mutagenicity of the psychoactive phenothiazine derivative perazine in vivo and in vitro.精神活性吩噻嗪衍生物奋乃静在体内和体外可能具有的致突变性。

Hum Genet. 1980;53(3):357-61. doi: 10.1007/BF00287056.

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