• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肉毒杆菌毒素在磨牙症所致继发性耳痛患者中的应用。

Application of Botulinum Toxin in Patients with Secondary Otalgia Caused by Bruxism.

作者信息

Kef Kemal

机构信息

Private Kesan Hospital, Department of ENT, Edirne, Turkey.

出版信息

J Pain Res. 2021 Apr 19;14:1051-1059. doi: 10.2147/JPR.S292550. eCollection 2021.

DOI:10.2147/JPR.S292550
PMID:33907453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8064681/
Abstract

AIM

The aim of this study was to determine the effectiveness of botulinum toxin administration in patients who consulted the otolaryngology clinic with secondary otalgia caused by bruxism.

INTRODUCTION

Botulinum toxin can be applied to the hypertrophic muscles in patients who suffer from facial asymmetry even though they do not experience pain. Injection intervals and the condition of the muscles should be monitored as botulinum toxin applications to the muscles may result in decreased muscle strength and chewing difficulties.

METHODS

This prospective study was conducted with bruxism patients at Private Kesan Hospital otorhinolaryngology outpatient clinic between August 2019 and December 2019. The diagnosis was based on the anamnesis and physical examination of the patient. The Visual Analogue Scale was used to evaluate patients' pain levels throughout the treatment.

RESULTS

A total of 37 patients, between 19 and 51 years old, 22 (59.46%) females and 15 (40.54%) males, who consulted to the otolaryngology clinic in Private Kesan Hospital between August 2019 and December 2019 with a diagnosis of otalgia caused by bruxism were included in the study. Nine patients (24.3%) had facial asymmetry due to masseter muscle hypertrophy. The average age of the participants was 34.00 ± 9.13 years old. Two weeks after the application of botulinum toxin, patients' complaints subsided. In patients with facial asymmetry, it was observed that asymmetry decreased after the 2nd month and noticeably improved after the 4th month.

DISCUSSION

Bruxism should be considered in the differential diagnosis of patients with ear pain. Botulinum toxin can be applied in patients who do not respond adequately to classical treatments such as medical treatments, chewing training, neck and facial muscle relaxation techniques, psychological support, and dental splint applications.

摘要

目的

本研究旨在确定向因磨牙症导致继发性耳痛而就诊于耳鼻喉科门诊的患者注射肉毒杆菌毒素的有效性。

引言

肉毒杆菌毒素可应用于面部不对称但无疼痛症状患者的肥厚肌肉。由于向肌肉注射肉毒杆菌毒素可能导致肌肉力量下降和咀嚼困难,因此应监测注射间隔和肌肉状况。

方法

本前瞻性研究于2019年8月至2019年12月在Kesan私立医院耳鼻喉科门诊对磨牙症患者进行。诊断基于患者的病史和体格检查。在整个治疗过程中,使用视觉模拟量表评估患者的疼痛程度。

结果

共有37例年龄在19至51岁之间的患者纳入研究,其中女性22例(59.46%),男性15例(40.54%),这些患者于2019年8月至2019年12月因磨牙症导致耳痛而就诊于Kesan私立医院耳鼻喉科门诊。9例患者(24.3%)因咬肌肥大出现面部不对称。参与者的平均年龄为34.00±9.13岁。注射肉毒杆菌毒素两周后,患者的症状有所缓解。在面部不对称的患者中,观察到在第2个月后不对称情况有所减轻,在第4个月后明显改善。

讨论

在耳痛患者的鉴别诊断中应考虑磨牙症。对于对药物治疗、咀嚼训练、颈部和面部肌肉放松技术、心理支持以及牙托应用等传统治疗反应不佳的患者,可应用肉毒杆菌毒素。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/1ce7d67fdc71/JPR-14-1051-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/82f6dafd3988/JPR-14-1051-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/6b01c5cb6d41/JPR-14-1051-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/d1cced9415e8/JPR-14-1051-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/ebeb95653eee/JPR-14-1051-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/4e186d6d495d/JPR-14-1051-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/dda905911b93/JPR-14-1051-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/ba8ccad3d240/JPR-14-1051-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/b5cdf1054bde/JPR-14-1051-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/a69bd5f781e6/JPR-14-1051-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/9f361f0ab976/JPR-14-1051-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/1ce7d67fdc71/JPR-14-1051-g0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/82f6dafd3988/JPR-14-1051-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/6b01c5cb6d41/JPR-14-1051-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/d1cced9415e8/JPR-14-1051-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/ebeb95653eee/JPR-14-1051-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/4e186d6d495d/JPR-14-1051-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/dda905911b93/JPR-14-1051-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/ba8ccad3d240/JPR-14-1051-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/b5cdf1054bde/JPR-14-1051-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/a69bd5f781e6/JPR-14-1051-g0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/9f361f0ab976/JPR-14-1051-g0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4df5/8064681/1ce7d67fdc71/JPR-14-1051-g0011.jpg

相似文献

1
Application of Botulinum Toxin in Patients with Secondary Otalgia Caused by Bruxism.肉毒杆菌毒素在磨牙症所致继发性耳痛患者中的应用。
J Pain Res. 2021 Apr 19;14:1051-1059. doi: 10.2147/JPR.S292550. eCollection 2021.
2
Botulinum toxin treatment of temporomandibular joint pain in patients with bruxism: A prospective and randomized clinical study.肉毒毒素治疗磨牙症患者颞下颌关节疼痛的前瞻性随机临床研究。
Niger J Clin Pract. 2021 Mar;24(3):412-417. doi: 10.4103/njcp.njcp_251_20.
3
Functional and esthetic effects of botulinum toxin injection into the masseter muscles: evaluation of 80 patients from a dermatological perspective.肉毒杆菌毒素注射咬肌的功能和美学效果:从皮肤科角度对80例患者的评估
Int J Dermatol. 2025 Jan;64(1):149-154. doi: 10.1111/ijd.17282. Epub 2024 Jun 4.
4
Comparison of clinical marking and ultrasound-guided injection of Botulinum type A toxin into the masseter muscles for treating bruxism and its cosmetic effects.A型肉毒杆菌毒素临床标记法与超声引导下注射咬肌治疗磨牙症及其美容效果的比较。
J Cosmet Dermatol. 2016 Sep;15(3):238-44. doi: 10.1111/jocd.12208. Epub 2016 Jan 22.
5
Evaluation of the Efficacy of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle for the Treatment of Nocturnal Bruxism: A Randomized Controlled Clinical Trial.低剂量肉毒杆菌毒素注射咬肌治疗夜磨牙症的疗效评估:一项随机对照临床试验
Cureus. 2022 Dec 4;14(12):e32180. doi: 10.7759/cureus.32180. eCollection 2022 Dec.
6
Efficacy of botulinum toxin in the management of temporomandibular myofascial pain and sleep bruxism.肉毒杆菌毒素在治疗颞下颌肌筋膜疼痛和磨牙症中的疗效。
J Korean Assoc Oral Maxillofac Surg. 2020 Oct 31;46(5):335-340. doi: 10.5125/jkaoms.2020.46.5.335.
7
Treatment of chronic pain associated with nocturnal bruxism with botulinum toxin. A prospective and randomized clinical study.肉毒杆菌毒素治疗与夜间磨牙相关的慢性疼痛。一项前瞻性随机临床研究。
J Clin Exp Dent. 2017 Jan 1;9(1):e112-e117. doi: 10.4317/jced.53084. eCollection 2017 Jan.
8
Does botulinum toxin have any role in the management of chronic pain associated with bruxism?肉毒杆菌毒素在治疗与磨牙症相关的慢性疼痛方面有作用吗?
Cranio. 2024 Mar;42(2):215-222. doi: 10.1080/08869634.2021.1949536. Epub 2021 Jul 14.
9
[Asymmetric hypertrophy of the masticatory muscles].[咀嚼肌不对称肥大]
Ann Chir Plast Esthet. 2012 Jun;57(3):286-91. doi: 10.1016/j.anplas.2012.02.014. Epub 2012 Mar 26.
10
The Evaluation of the Relationship between Changes in Masseter Muscle Thickness and Tooth Clenching Habits of Bruxism Patients Treated with Botulinum Toxin A.A型肉毒杆菌毒素治疗磨牙症患者咬肌厚度变化与紧咬牙习惯之间关系的评估
J Med Ultrasound. 2022 Aug 18;31(1):22-28. doi: 10.4103/jmu.jmu_51_22. eCollection 2023 Jan-Mar.

引用本文的文献

1
Efficacy and Safety of Botulinum Toxin in the Management of Temporomandibular Symptoms Associated with Sleep Bruxism: A Systematic Review.肉毒杆菌毒素治疗与磨牙症相关的颞下颌症状的疗效和安全性:一项系统评价
Dent J (Basel). 2024 May 23;12(6):156. doi: 10.3390/dj12060156.
2
Can botulinum toxin injection alleviate the pain of bruxism? A Bayesian network analysis and a single-arm analysis.肉毒杆菌毒素注射能缓解磨牙症的疼痛吗?一项贝叶斯网络分析和单臂分析。
J Dent Sci. 2024 Apr;19(2):885-893. doi: 10.1016/j.jds.2023.08.001. Epub 2023 Aug 22.
3
Effectiveness of Botulinum Toxin Injection on Bruxism: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

本文引用的文献

1
When should sleep bruxism be considered in the diagnosis of temporomandibular disorders?在诊断颞下颌关节紊乱时何时应考虑睡眠磨牙症?
Oral Surg Oral Med Oral Pathol Oral Radiol. 2020 Dec;130(6):645-650. doi: 10.1016/j.oooo.2020.08.029. Epub 2020 Aug 29.
2
Application of botulinum toxin in maxillofacial field: part I. Bruxism and square jaw.肉毒杆菌毒素在颌面领域的应用:第一部分。磨牙症与方脸。
Maxillofac Plast Reconstr Surg. 2019 Oct 1;41(1):38. doi: 10.1186/s40902-019-0218-0. eCollection 2019 Dec.
3
Evaluation of Orofacial and General Pain Location in Patients With Temporomandibular Joint Disorder-Myofascial Pain With Referral.
肉毒杆菌毒素注射治疗磨牙症的有效性:随机对照试验的系统评价和荟萃分析
Aesthetic Plast Surg. 2023 Apr;47(2):775-790. doi: 10.1007/s00266-023-03256-8. Epub 2023 Jan 24.
4
Aetiology and management options for secondary referred otalgia: a systematic review and meta-analyses.继发性牵涉性耳痛的病因及处理方法:一项系统评价与荟萃分析
Eur Arch Otorhinolaryngol. 2023 Jan;280(1):47-59. doi: 10.1007/s00405-022-07638-7. Epub 2022 Sep 26.
5
Unusual Case of Masseter Muscle Hypertrophy in Adolescence-Case Report and Literature Overview.青少年咬肌肥大的罕见病例——病例报告与文献综述
Diagnostics (Basel). 2022 Feb 16;12(2):505. doi: 10.3390/diagnostics12020505.
颞下颌关节紊乱病-肌筋膜疼痛伴牵涉痛患者口面部及全身疼痛部位的评估
Front Neurol. 2019 May 29;10:546. doi: 10.3389/fneur.2019.00546. eCollection 2019.
4
The prevalence of awake bruxism and sleep bruxism in the Dutch adult population.荷兰成年人群中清醒磨牙症和睡眠磨牙症的患病率。
J Oral Rehabil. 2019 Jul;46(7):617-623. doi: 10.1111/joor.12787. Epub 2019 Apr 2.
5
Clear aligners' effects on aesthetics: evaluation of facial wrinkles.透明矫治器对面部美学的影响:面部皱纹评估
J Clin Exp Dent. 2018 Jul 1;10(7):e696-e701. doi: 10.4317/jced.54925. eCollection 2018 Jul.
6
The Evaluation of the Clinical Effects of Botulinum Toxin on Nocturnal Bruxism.肉毒杆菌毒素对夜间磨牙症临床疗效的评估
Pain Res Manag. 2017;2017:6264146. doi: 10.1155/2017/6264146. Epub 2017 Jul 5.
7
Therapies for bruxism: a systematic review and network meta-analysis (protocol).磨牙症的治疗:系统评价与网状Meta分析(方案)
Syst Rev. 2017 Jan 13;6(1):4. doi: 10.1186/s13643-016-0397-z.
8
Parafunctional habits are associated cumulatively to painful temporomandibular disorders in adolescents.功能性异常习惯与青少年颞下颌关节紊乱疼痛累积相关。
Braz Oral Res. 2016;30. doi: 10.1590/1807-3107BOR-2016.vol30.0015. Epub 2016 Feb 23.
9
Bruxism: Conceptual discussion and review.磨牙症:概念探讨与综述。
J Pharm Bioallied Sci. 2015 Apr;7(Suppl 1):S265-70. doi: 10.4103/0975-7406.155948.
10
Bruxism: a literature review.磨牙症:文献综述
J Int Oral Health. 2014 Nov-Dec;6(6):105-9.