State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, 610041, Sichuan, People's Republic of China.
Signal Transduct Target Ther. 2023 Dec 21;8(1):466. doi: 10.1038/s41392-023-01724-w.
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant casualties and put immense strain on public health systems worldwide, leading to economic recession and social unrest. In response, various prevention and control strategies have been implemented globally, including vaccine and drug development and the promotion of preventive measures. Implementing these strategies has effectively curbed the transmission of the virus, reduced infection rates, and gradually restored normal social and economic activities. However, the mutations of SARS-CoV-2 have led to inevitable infections and reinfections, and the number of deaths continues to rise. Therefore, there is still a need to improve existing prevention and control strategies, mainly focusing on developing novel vaccines and drugs, expediting medical authorization processes, and keeping epidemic surveillance. These measures are crucial to combat the Coronavirus disease (COVID-19) pandemic and achieve sustained, long-term prevention, management, and disease control. Here, we summarized the characteristics of existing COVID-19 vaccines and drugs and suggested potential future directions for their development. Furthermore, we discussed the COVID-19-related policies implemented over the past years and presented some strategies for the future.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的传播导致了重大人员伤亡，并对全球公共卫生系统造成了巨大压力，导致经济衰退和社会动荡。为此，全球范围内实施了各种预防和控制策略，包括疫苗和药物的开发以及预防措施的推广。实施这些策略有效地遏制了病毒的传播，降低了感染率，并逐步恢复了正常的社会和经济活动。然而，SARS-CoV-2 的突变导致了不可避免的感染和再次感染，死亡人数仍在上升。因此，仍有必要改进现有的预防和控制策略，主要集中在开发新型疫苗和药物、加快医疗授权程序和保持疫情监测上。这些措施对于应对冠状病毒病（COVID-19）大流行以及实现持续、长期的预防、管理和疾病控制至关重要。在这里，我们总结了现有 COVID-19 疫苗和药物的特点，并提出了它们未来发展的潜在方向。此外，我们还讨论了过去几年实施的 COVID-19 相关政策，并提出了一些未来的策略。
