Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
Department of Ophthalmology, Izmir Tepecik Training and Research Hospital, Health Sciences University, Izmir, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2021 Sep;259(9):2821-2826. doi: 10.1007/s00417-021-05209-w. Epub 2021 Apr 27.
To recognize dysfunctions in the autonomic nervous system (ANS) with changes in dynamic and static pupillary responses in patients who recovered from coronavirus disease-2019 (COVID-19) METHODS: One month after recovery from COVID-19, patients were subjected to eye examinations. Pupillary responses were measured using a pupillometry system. Dynamic pupil parameters (i.e., pupil contraction amplitude, pupil dilatation latency, pupil contraction latency, pupil dilatation duration, pupil dilatation velocity, pupil contraction duration, pupil contraction velocity, resting pupil diameter [PD]) and static pupil parameters (i.e., mesopic PD, scotopic PD, high photopic PD, and low photopic PD) were registered.
Although high photopic and scotopic PDs were significantly higher in patients recovering from COVID-19 than in healthy controls (P = 0.04 and P = 0.002), no statistically significant difference was found in mesopic and low photopic PD (P = 0.19 and P = 0.41). Regarding dynamic pupillometry parameters, resting PD and pupil contraction velocity (P = 0.04 and P = 0.02, respectively) were significantly higher in patients recovering from COVID-19 than in healthy controls (P < 0.001 and P < 0.001, respectively), whereas pupil dilatation latency and pupil contraction duration were lower in these patients than in healthy controls (P = 0.01 and P = 0.008, respectively). No significant differences in pupil contraction amplitude, pupil dilatation duration, pupil contraction latency, and pupil dilatation velocity were found between the study groups (P = 0.93, P = 0.91, P = 0.42, and P = 0.48, respectively).
Pupil responses, which are controlled by the ANS, were impaired in patients recovering from COVID-19. Pupillometry shows promise as a non-invasive, easy-to-apply diagnostic technology for detecting autonomic dysfunction in patients recovering from COVID-19.
Not applicable.
通过测量新冠肺炎（COVID-19）康复患者的动态和静态瞳孔反应，识别自主神经系统（ANS）功能障碍。
在 COVID-19 康复后 1 个月，对患者进行眼部检查。使用瞳孔测量系统测量瞳孔反应。记录动态瞳孔参数（即瞳孔收缩幅度、瞳孔扩张潜伏期、瞳孔收缩潜伏期、瞳孔扩张持续时间、瞳孔扩张速度、瞳孔收缩持续时间、瞳孔收缩速度、静止瞳孔直径[PD]）和静态瞳孔参数（即中间光 PD、暗 PD、高光 PD 和低光 PD）。
尽管 COVID-19 康复患者的高和暗光 PD 明显高于健康对照组（P=0.04 和 P=0.002），但中间光和低光 PD 无统计学差异（P=0.19 和 P=0.41）。在动态瞳孔测量参数方面，COVID-19 康复患者的静止 PD 和瞳孔收缩速度（P=0.04 和 P=0.02）明显高于健康对照组（P<0.001 和 P<0.001），而瞳孔扩张潜伏期和瞳孔收缩持续时间则低于健康对照组（P=0.01 和 P=0.008）。两组间瞳孔收缩幅度、瞳孔扩张持续时间、瞳孔收缩潜伏期和瞳孔扩张速度无显著差异（P=0.93、P=0.91、P=0.42 和 P=0.48）。
受 ANS 控制的瞳孔反应在 COVID-19 康复患者中受损。瞳孔测量法作为一种非侵入性、易于应用的诊断技术，有望用于检测 COVID-19 康复患者的自主神经功能障碍。
不适用。
