College of Life Science, Shandong Agricultural University, Taian, 271018, PR China.
Food Funct. 2021 May 21;12(10):4591-4605. doi: 10.1039/d1fo00310k. Epub 2021 Apr 28.
A polysaccharide named PFP-1 was isolated from the Pleurotus geesteranus fruiting body, and potential investigations on ameliorating oxidative stress and liver injury against alcoholic liver disease (ALD) were performed in mice. The animal studies demonstrated that PFP-1 had hepatoprotective effects by improving hepatocellular histopathology, modulating alcohol metabolisms and restoring the serum lipid levels. Besides, PFP-1 could attenuate oxidative stress and inflammatory responses by activating the Nrf2-mediated signal pathways and regulating the TLR4-mediated NF-κB signal pathways. The characterization indicated that PFP-1 was a typical pyranose-polysaccharide in a triple-helical conformation, which was linked by t-β-Glcp, 1,6-α-Glcp and 1,2,6-α-Galp. And the characteristic properties of higher water solubility and appropriate molecular weights contributed to the superior bioactivities. The results demonstrated that PFP-1 could be used as a supplement for alleviating alcohol-induced liver damage.
从杏鲍菇子实体中分离得到一种多糖命名为 PFP-1，在小鼠中对其改善氧化应激和肝损伤对抗酒精性肝病（ALD）的潜力进行了研究。动物研究表明，PFP-1 通过改善肝细胞组织病理学、调节酒精代谢和恢复血清脂质水平发挥肝保护作用。此外，PFP-1 通过激活 Nrf2 介导的信号通路和调节 TLR4 介导的 NF-κB 信号通路来减轻氧化应激和炎症反应。表征表明，PFP-1 是一种典型的三螺旋构象吡喃糖多糖，由 t-β-Glcp、1,6-α-Glcp 和 1,2,6-α-Galp 连接。高水溶性和适当分子量的特征特性有助于优异的生物活性。结果表明，PFP-1 可用作缓解酒精性肝损伤的补充剂。
