Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei, China.
Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, Hefei, China.
Neuroendocrinology. 2022;112(4):311-323. doi: 10.1159/000516881. Epub 2021 Apr 29.
Biomonitoring of bisphenol A (BPA) in human blood is still scarce, although already noticeable. We aimed to examine the associations between prenatal serum BPA concentrations and behavior and cognitive function in preschool children.
A total of 1,782 mother-child pairs with complete demographic information, blood samples, and psychological measurements were included from the China-Anhui Birth Cohort (C-ABCS). We detected serum BPA concentrations and assessed children's neurodevelopment using a set of psychometric scales.
The median prenatal maternal serum BPA concentration was 0.23 (P25, P75: 0.07, 0.52) ng/mL, with a detection frequency of 85.19%. Compared with the girls with the lowest concentrations, those with highest BPA concentrations had increased risks of inhibitory self-control impairment [relative risk (RR) = 3.66, 95% confidence interval (CI): 1.53, 7.58], emergent metacognition impairment (RR = 1.70, 95% CI: 1.07, 2.78), conduct problem (RR = 1.68, 95% CI: 1.12, 2.39), peer relationship problem (RR = 2.57, 95% CI: 1.33, 4.47), higher total difficulties score (RR = 1.76, 95% CI: 1.12, 2.67), and higher impact factor score (RR = 1.52, 95% CI: 1.11, 2.05), while the boys with the highest prenatal BPA concentrations had an increased risk of conduct problem compared with those with the lowest concentrations (RR = 1.59, 95% CI: 1.09, 2.24) (P-interaction = 0.011). After stratification by age, high prenatal BPA concentrations were associated with increased ADHD (RR = 4.44, 95% CI: 1.54, 10.85) among children aged 3 years, not among children aged 4 years.
Our study revealed the sex-specific and age-specific impacts of prenatal BPA exposure on preschool children's cognitive and behavioral development.
人体血液中双酚 A（BPA）的生物监测仍然很少见，尽管已经很明显了。我们旨在研究产前血清 BPA 浓度与学龄前儿童行为和认知功能之间的关系。
共有 1782 对母子配对的完整人口统计学信息、血液样本和心理测量结果来自中国-安徽出生队列（C-ABCS）。我们检测了血清 BPA 浓度，并使用一系列心理计量学量表评估了儿童的神经发育情况。
母亲产前血清 BPA 浓度中位数为 0.23（P25，P75：0.07，0.52）ng/mL，检测频率为 85.19%。与浓度最低的女孩相比，浓度最高的女孩出现抑制自我控制障碍的风险增加[相对风险（RR）=3.66，95%置信区间（CI）：1.53，7.58]、出现元认知障碍（RR=1.70，95%CI：1.07，2.78）、行为问题（RR=1.68，95%CI：1.12，2.39）、同伴关系问题（RR=2.57，95%CI：1.33，4.47）、总困难评分更高（RR=1.76，95%CI：1.12，2.67）和影响因素评分更高（RR=1.52，95%CI：1.11，2.05），而浓度最高的男孩与浓度最低的男孩相比，出现行为问题的风险增加（RR=1.59，95%CI：1.09，2.24）（P 交互=0.011）。按年龄分层后，高浓度的产前 BPA 与 3 岁儿童的 ADHD 增加相关（RR=4.44，95%CI：1.54，10.85），但与 4 岁儿童无关。
我们的研究揭示了产前 BPA 暴露对学龄前儿童认知和行为发展的性别特异性和年龄特异性影响。
