Guo Wei, Ding Xiaoyue, Zhang Han, Liu Zhenzhong, Han Yanting, Wei Qianqian, Okoro Oseweuba Valentine, Shavandi Amin, Nie Lei
College of Life Sciences, Xinyang Normal University, Xinyang 464000, China.
Taizhou Key Laboratory of Medical Devices and Advanced Materials, Taizhou Institute of Zhejiang University, Taizhou 318000, China.
Gels. 2024 Feb 29;10(3):175. doi: 10.3390/gels10030175.
The management of wound healing represents a significant clinical challenge due to the complicated processes involved. Chitosan has remarkable properties that effectively prevent certain microorganisms from entering the body and positively influence both red blood cell aggregation and platelet adhesion and aggregation in the bloodstream, resulting in a favorable hemostatic outcome. In recent years, chitosan-based hydrogels have been widely used as wound dressings due to their biodegradability, biocompatibility, safety, non-toxicity, bioadhesiveness, and soft texture resembling the extracellular matrix. This article first summarizes an overview of the main chemical modifications of chitosan for wound dressings and then reviews the desired properties of chitosan-based hydrogel dressings. The applications of chitosan-based hydrogels in wound healing, including burn wounds, surgical wounds, infected wounds, and diabetic wounds are then discussed. Finally, future prospects for chitosan-based hydrogels as wound dressings are discussed. It is anticipated that this review will form a basis for the development of a range of chitosan-based hydrogel dressings for clinical treatment.
由于伤口愈合过程复杂，其管理是一项重大的临床挑战。壳聚糖具有显著特性，能有效防止某些微生物进入体内，并对血液中红细胞聚集以及血小板黏附和聚集产生积极影响，从而带来良好的止血效果。近年来，基于壳聚糖的水凝胶因其生物可降解性、生物相容性、安全性、无毒性、生物黏附性以及类似细胞外基质的柔软质地，已被广泛用作伤口敷料。本文首先总结了用于伤口敷料的壳聚糖主要化学修饰的概述，然后回顾了基于壳聚糖的水凝胶敷料的理想特性。接着讨论了基于壳聚糖的水凝胶在伤口愈合中的应用，包括烧伤伤口、手术伤口、感染伤口和糖尿病伤口。最后，探讨了基于壳聚糖的水凝胶作为伤口敷料的未来前景。预计这篇综述将为开发一系列用于临床治疗的基于壳聚糖的水凝胶敷料奠定基础。
