Medical Research Laboratory, Bacteriology-LIM-54, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Infectious Diseases, Postgraduate Program in Health Science, Pontifical Catholic University of Campinas (Puc-Campinas) Center of Life Science, Campinas, Brazil.
Transpl Infect Dis. 2021 Aug;23(4):e13630. doi: 10.1111/tid.13630. Epub 2021 May 18.
Surveillance programs have been reporting decreasing rates of carbapenem-sensitivity in Serratia marcescens, leading to a concern regarding the few remaining therapeutic options to treat these multidrug-resistant (MDR) organisms. Here, we describe a case series of 11 stem cell hematopoietic transplantation patients infected (N = 6) or colonized (N = 5) by carbapenem-resistant S marcescens (CrSm) from 2010 to 2013. The comorbidities found were acute renal insufficiency (3/11), neutropenia (7/11), and mucositis (8/11), and the mortality rate was 64%. KPC was the most prevalent carbapenemase detected (8/11) and tigecycline and gentamicin were the antimicrobials used as treatment.
监测项目报告显示，黏质沙雷氏菌对碳青霉烯类药物的敏感性呈下降趋势，这使得人们对治疗这些多药耐药（MDR）生物体为数不多的剩余治疗选择产生了担忧。在这里，我们描述了 2010 年至 2013 年间，11 例干细胞造血移植患者感染（N=6）或定植（N=5）碳青霉烯类耐药黏质沙雷氏菌（CrSm）的病例系列。发现的合并症有急性肾功能不全（3/11）、中性粒细胞减少症（7/11）和黏膜炎（8/11），死亡率为 64%。KPC 是检测到的最常见的碳青霉烯酶（8/11），替加环素和庆大霉素被用作治疗药物。
