Gul Hashmat, Nayyer Maleeha, Gilani Mehreen, Aman Nadia, Azad Azad Ali, Shah Asma Tufail, Chaudhry Aqif Anwar, Kaleem Muhammad, Khan Abdul Samad
Department of Dental Materials, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.
Department of Microbiology, Army Medical College, National University of Medical Sciences, Rawalpindi, Pakistan.
Eur J Dent. 2020 Feb;14(1):38-44. doi: 10.1055/s-0040-1701292. Epub 2020 Feb 4.
The objectives were to measure fluoride release and assess the antimicrobial behavior of fluoride-doped nano bioactive glass (F-nBG) and nano zinc oxide (ZnO)-enriched novel dentifrices.
Experimental dentifrices were synthesized by incorporating ZnO nanoparticles and F-nBG (1.5 wt% and 4 wt%) as active ingredients. The fluoride release behavior of suspensions and elutes of samples were analyzed by ion selective electrode. Antimicrobial activity and minimum bactericidal concentration against and were evaluated. Microbial stability against contamination was also assessed by a challenge test.
The fluoride release behavior of experimental dentifrices was higher than that of commercial dentifrices and was dependent on filler loading. The fluoride release was more from suspensions than elutes. Zones of inhibition (ZOIs) and minimum bactericidal concentration values for novel dentifrices showed direct proportionality with filler loading, and effectiveness was exhibited against both strains. Experimental dentifrices exhibited effective antibacterial potential, which could possibly be due to release of sufficient fluoride and zinc ions in aqueous media from F-nBG and ZnO present in their formulations.
Combination of F-nBG and ZnO may provide a multi-benefit approach for simultaneously treating early white spot lesions, reducing bacterial growth, and providing core plaque control.
本研究旨在测定氟化物释放量，并评估掺氟纳米生物活性玻璃（F-nBG）和富含纳米氧化锌（ZnO）的新型牙膏的抗菌性能。
通过加入ZnO纳米颗粒和F-nBG（1.5 wt%和4 wt%）作为活性成分合成实验性牙膏。采用离子选择性电极分析样品悬浮液和洗脱液的氟化物释放行为。评估了对[具体细菌名称1]和[具体细菌名称2]的抗菌活性及最低杀菌浓度。还通过挑战性试验评估了对污染的微生物稳定性。
实验性牙膏的氟化物释放量高于市售牙膏，且取决于填料含量。悬浮液中的氟化物释放量高于洗脱液。新型牙膏的抑菌圈（ZOIs）和最低杀菌浓度值与填料含量成正比，且对两种菌株均有抗菌效果。实验性牙膏表现出有效的抗菌潜力，这可能是由于其配方中的F-nBG和ZnO在水性介质中释放了足够的氟离子和锌离子。
F-nBG和ZnO的组合可能为同时治疗早期白斑病变、减少细菌生长和控制牙菌斑提供一种多效方法。
