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生物合成纳米复合材料的交互作用及其抗菌和细胞毒性潜力

Interactive Effects of Biosynthesized Nanocomposites and Their Antimicrobial and Cytotoxic Potentials.

作者信息

El-Kahky Dina, Attia Magdy, Easa Saadia M, Awad Nemat M, Helmy Eman A

机构信息

Microbiology Department, Faculty of Science, Ain Shams University, Cairo 11566, Egypt.

Agricultural Microbiology Department, National Research Centre, 33 El-Bohouth Street, (Former El-Tahrir Street) Dokki, Giza 12622, Egypt.

出版信息

Nanomaterials (Basel). 2021 Apr 1;11(4):903. doi: 10.3390/nano11040903.

DOI:10.3390/nano11040903
PMID:33916082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8067103/
Abstract

The present study investigated the biosynthesis of silver (AgNPs), zinc oxide (ZnONPs) and titanium dioxide (TiONPs) nanoparticles using , and . Nanocomposites (NCs) were successfully synthesized by mixing nanoparticles using a Sonic Vibra-Cell VC/VCX processor. A number of analytical techniques were used to characterize the synthesized biological metal nanoparticles. Several experiments tested biologically synthesized metal nanoparticles and nanocomposites against two types of human pathogenic bacteria, including Gram-positive and methicillin-resistant (MRSA), and Gram-negative and . Additionally, the antitumor activity in HCT-116 cells (colonic carcinoma) was also evaluated. Significant antimicrobial effects of various synthesized forms of nanoparticles and nanocomposites against and bacteria were detected. Various synthesized biogenic forms of nanoparticles and nanocomposite (9.0 to 29 mm in diameter) had high antibacterial activity and high antitumor activity against HCT-116 cells (colonic carcinoma) with IC values of 0.7-100 µg/mL. Biosynthesized NPs are considered an alternative to large-scale biosynthesized metallic nanoparticles and nanocomposites, are simple and cost effective, and provide stable nanomaterials.

摘要

本研究使用[具体物质1]、[具体物质2]和[具体物质3]研究了银纳米颗粒（AgNPs）、氧化锌纳米颗粒（ZnONPs）和二氧化钛纳米颗粒（TiONPs）的生物合成。通过使用Sonic Vibra-Cell VC/VCX处理器混合纳米颗粒成功合成了纳米复合材料（NCs）。使用了多种分析技术来表征合成的生物金属纳米颗粒。进行了多项实验，测试了生物合成的金属纳米颗粒和纳米复合材料对两种人类病原菌的抗菌性能，包括革兰氏阳性菌[具体细菌1]和耐甲氧西林[具体细菌2]（MRSA），以及革兰氏阴性菌[具体细菌3]和[具体细菌4]。此外，还评估了其对HCT-116细胞（结肠癌）的抗肿瘤活性。检测到各种合成形式的纳米颗粒和纳米复合材料对[具体细菌1]和[具体细菌2]具有显著的抗菌作用。各种合成的生物源形式的纳米颗粒和纳米复合材料（直径9.0至29毫米）对HCT-116细胞（结肠癌）具有高抗菌活性和高抗肿瘤活性，IC值为0.7 - 100 µg/mL。生物合成的纳米颗粒被认为是大规模生物合成金属纳米颗粒和纳米复合材料的替代品，方法简单且成本效益高，并提供了稳定的纳米材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7117/8067103/1f46dea829e7/nanomaterials-11-00903-g015.jpg
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