Orozco-Beltrán Domingo, Arriero-Marin Juan Manuel, Carratalá-Munuera Concepción, Soler-Cataluña Juan J, Lopez-Pineda Adriana, Gil-Guillén Vicente F, Quesada Jose A
Department of Clinical Medicine, Miguel Hernández University, 03550 San Juan de Alicante, Spain.
Pneumology Department, University Hospital of San Juan de Alicante, 03550 San Juan de Alicante, Spain.
J Clin Med. 2021 Apr 6;10(7):1529. doi: 10.3390/jcm10071529.
The prevalence of chronic obstructive pulmonary disease (COPD) is rising faster in women in some countries. An observational time trends study was performed to assess the evolution of hospital admissions for COPD in men and women in Spain from 1998 to 2018. ICD-9 diagnostic codes (490-492, 496) from the minimum basic data set of hospital discharges were used. Age-standardised admission rates were calculated using the European Standard Population. Joinpoint regression models were fitted to estimate the annual percent change (APC). In 2018, the age-standardised admission rate per 100,000 population/year for COPD was five times higher in men (384.8, 95% CI: 381.7, 387.9) than in women (78.6, 95% CI: 77.4, 79.9). The average annual percent change (AAPC) was negative over the whole study period in men (-1.7%/year, 95% CI: -3.1, -0.2) but positive from 2010 to 2018 (1.1%/year, 95% CI: -0.8, 2.9). In women, the APC was -6.0% (95%CI: -7.1, -4.9) from 1998 to 2010, but the trend reversed direction in the 2010-2018 period (7.8%/year, 95% CI: 5.5, 10.2). Thus, admission rates for COPD decreased from 1998 to 2010 in both men and women but started rising again until 2018, modestly in men and sharply in women.
在一些国家，慢性阻塞性肺疾病（COPD）在女性中的患病率上升速度更快。开展了一项观察性时间趋势研究，以评估1998年至2018年西班牙男性和女性因COPD住院的演变情况。使用了医院出院最小基本数据集的ICD - 9诊断代码（490 - 492、496）。采用欧洲标准人口计算年龄标准化住院率。拟合连接点回归模型以估计年度百分比变化（APC）。2018年，COPD的年龄标准化住院率为每10万人口/年，男性（384.8，95%置信区间：381.7，387.9）是女性（78.6，95%置信区间：77.4，79.9）的五倍。在整个研究期间，男性的平均年度百分比变化（AAPC）为负（-1.7%/年，95%置信区间：-3.1，-0.2），但在2010年至2018年为正（1.1%/年，95%置信区间：-0.8，2.9）。在女性中，1998年至2010年的APC为-6.0%（95%置信区间：-7.1，-4.9），但在2010 - 2018年期间趋势逆转（7.8%/年，95%置信区间：5.5，10.2）。因此，1998年至2010年男性和女性因COPD的住院率均下降，但到2018年又开始再次上升，男性上升幅度较小，女性上升幅度较大。
