Department of Biotechnology, Institute of Natural Fibres and Medicinal Plants-State Research Institute, Wojska Polskiego 71B, 60-630 Poznań, Poland.
Chair and Department of Medical Microbiology, Poznań University of Medical Sciences, Wieniawskiego 3, 61-712 Poznań, Poland.
Int J Mol Sci. 2021 Apr 21;22(9):4294. doi: 10.3390/ijms22094294.
As the major nonpsychotropic constituent of , cannabidiol (CBD) is regarded as one of the most promising therapeutic agents due to its proven effectiveness in clinical trials for many human diseases. Due to the urgent need for more efficient pharmacological treatments for several chronic diseases, in this review, we discuss the potential beneficial effects of CBD for Alzheimer's disease, epilepsy, multiple sclerosis, and neurological cancers. Due to its wide range of pharmacological activities (e.g., antioxidant, anti-inflammatory, and neuroprotective properties), CBD is considered a multimodal drug for the treatment of a range of neurodegenerative disorders, and various cancer types, including neoplasms of the neural system. The different mechanisms of action of CBD are here disclosed, together with recent progress in the use of this cannabis-derived constituent as a new therapeutic approach.
大麻素的主要非精神活性成分大麻二酚（CBD），因其在临床试验中对多种人类疾病的显著疗效，被认为是最有前途的治疗药物之一。鉴于对多种慢性疾病更有效的药理学治疗方法的迫切需求，在这篇综述中，我们讨论了 CBD 对阿尔茨海默病、癫痫、多发性硬化症和神经癌的潜在有益作用。由于 CBD 具有广泛的药理活性（如抗氧化、抗炎和神经保护特性），因此被认为是一种多模式药物，可用于治疗一系列神经退行性疾病和各种癌症类型，包括神经系统肿瘤。本文揭示了 CBD 的不同作用机制，并介绍了使用这种源自大麻的成分作为新的治疗方法的最新进展。
