Hancu Gabriel, Papp Lajos Attila, Tóth Gergő, Kelemen Hajnal
Department of Pharmaceutical and Therapeutic Chemistry, Faculty of Pharmacy, University of Medicine, Pharmacy, Science and Technology "George Emil Palade" of Târgu Mureș, 540142 Târgu Mureș, Romania.
Department of Pharmaceutical Chemistry, Semmelweis University, H-1092 Budapest, Hungary.
Molecules. 2021 Apr 14;26(8):2261. doi: 10.3390/molecules26082261.
Cyclodextrin (CD) derivatives are the most efficient and frequently used chiral selectors (CSs) in capillary electrophoresis (CE). There are situations when the use of a single CD as CS is not enough to obtain efficient chiral discrimination of the enantiomers; in these cases, sometimes this problem can be resolved using a dual CD system. The use of dual CD systems can often dramatically enhance enantioseparation selectivity and can be applied for the separation of many analytes of pharmaceutical interest for which enantioseparation by CE with another CS systems can be problematic. Usually in a dual CD system an anionic CD is used together with a neutral one, but there are situations when the use of a cationic CD with a neutral one or the use of two neutral CDs or even two ionized CDs can be an efficient solution. In the current review we present general aspects of the use of dual CD systems in the analysis of pharmaceutical substances. Several examples of applications of the use of dual CD systems in the analysis of pharmaceuticals are selected and discussed. Theoretical aspects regarding the separation of enantiomers through simultaneous interaction with the two CSs are also explained. Finally, advantages, disadvantages, potential and new direction in this chiral analysis field are highlighted.
环糊精（CD）衍生物是毛细管电泳（CE）中最有效且最常用的手性选择剂（CSs）。在某些情况下，使用单一的环糊精作为手性选择剂不足以实现对映体的高效手性分离；在这些情况下，有时可以使用双环糊精系统解决该问题。双环糊精系统的使用通常可以显著提高对映体分离的选择性，并且可用于分离许多具有药学意义的分析物，而对于这些分析物，使用其他手性选择剂系统通过毛细管电泳进行对映体分离可能会存在问题。通常在双环糊精系统中，阴离子型环糊精与中性环糊精一起使用，但在某些情况下，使用阳离子型环糊精与中性环糊精、或使用两种中性环糊精、甚至两种离子化环糊精也可能是一种有效的解决方案。在当前的综述中，我们介绍了双环糊精系统在药物分析中的一般应用情况。选取并讨论了双环糊精系统在药物分析中应用的几个实例。还解释了通过与两种手性选择剂同时相互作用来分离对映体的理论方面。最后，强调了该手性分析领域的优点、缺点、潜力和新方向。
