一种基于FeO-SWCNTs/离子液体糊剂传感器的用于达沙替尼抗癌药物传感的新型电化学平台。

A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using FeO-SWCNTs/Ionic Liquid Paste Sensor.

作者信息

Moghaddam Ali, Zamani Hassan Ali, Karimi-Maleh Hassan

机构信息

Department of Applied Chemistry, Mashhad Branch, Islamic Azad University, Mashhad 9187147578, Iran.

Laboratory of Nanotechnology, Department of Chemical Engineering and Energy, Quchan University of Technology, Quchan 9477177870, Iran.

出版信息

Micromachines (Basel). 2021 Apr 14;12(4):437. doi: 10.3390/mi12040437.

A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with FeO-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF). The new platform showed a linear dynamic range from 0.001-220 µM with a detection limit of 0.7 nM to determine DA at optimal condition. Electrochemical investigation showed that the redox reaction of DA is relative to changing the pH of solution. Moreover, FeO-SWCNTs/mim-BF/PE has improved the oxidation current of DA about 5.58 times which reduced its oxidation potential by about 120 mV at optimal condition. In the final step, FeO-SWCNTs/mim-BF/PE was used as an analytical platform to determine the DA in tablets and a dextrose saline spike sample, and the results showed recovery data 99.58-103.6% which confirm the powerful ability of the sensor as an analytical tool to determine the DA in real samples.

基于用FeO-SWCNTs纳米复合材料和1-己基-3-甲基咪唑四氟硼酸盐（mim-BF）放大的糊电极修饰（PE），提出了一种用于检测达沙替尼（DA）抗癌药物的新型电化学平台。该新型平台在最佳条件下测定DA时，线性动态范围为0.001 - 220 µM，检测限为0.7 nM。电化学研究表明，DA的氧化还原反应与溶液pH值的变化有关。此外，在最佳条件下，FeO-SWCNTs/mim-BF/PE使DA的氧化电流提高了约5.58倍，其氧化电位降低了约120 mV。最后，FeO-SWCNTs/mim-BF/PE被用作分析平台来测定片剂和葡萄糖盐水加标样品中的DA，结果显示回收率数据为99.58 - 103.6%，这证实了该传感器作为分析工具测定实际样品中DA的强大能力。