St Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia.
Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria 3000, Australia.
Int J Mol Sci. 2021 Apr 14;22(8):4052. doi: 10.3390/ijms22084052.
As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing the well-being and quality of life of sufferers and their families. In recent decades, due to reduced work-related levels of physical activity, and key research insights, prescribing adequate exercise has become an innovative strategy to prevent or delay the onset of these pathologies and has been demonstrated to have therapeutic benefits when used as a sole or combination treatment. Recent evidence suggests that the beneficial effects of exercise on the brain are related to several underlying mechanisms related to muscle-brain, liver-brain and gut-brain crosstalk. Therefore, this review aims to summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and to highlight the established and potential underlying mechanisms involved in exercise-brain communication and their benefits for physiology and brain function.
随着医疗进步和经济繁荣，人类预期寿命，尤其是在发达国家，得以延长，与年龄相关的神经退行性疾病和精神健康障碍成为更普遍的健康问题，降低了患者及其家属的幸福感和生活质量。近几十年来，由于工作相关体力活动减少，以及关键的研究进展，开具足够的运动处方成为预防或延缓这些疾病发生的创新策略，并且已被证明在单独使用或联合治疗时具有治疗益处。最近的证据表明，运动对大脑的有益影响与肌肉-大脑、肝脏-大脑和肠道-大脑串扰相关的几个潜在机制有关。因此，本综述旨在总结运动对情绪障碍和神经退行性疾病影响的最相关的现有知识，并强调运动-大脑交流中涉及的已建立和潜在的潜在机制及其对生理学和大脑功能的益处。
