Mota-Rojas Daniel, Napolitano Fabio, Strappini Ana, Orihuela Agustín, Ghezzi Marcelo Daniel, Hernández-Ávalos Ismael, Mora-Medina Patricia, Whittaker Alexandra L
Neurophysiology, Behavior and Animal Welfare Assessment, DPAA, Universidad Autónoma Metropolitana, Xochimilco Campus, 04960 Ciudad de México, Mexico.
Scuola di Scienze Agrarie, Forestali, Alimentari ed Ambientali, Università degli Studi della Basilicata, 85100 Potenza, Italy.
Animals (Basel). 2021 Apr 10;11(4):1085. doi: 10.3390/ani11041085.
We pose, based on a neurobiological examination, that events that occur around the time of slaughter have the potential to intensify the pain response, through the processes of sensitisation and enhanced transmission. Sensitisation, or an enhanced response to painful stimuli, is a well-discussed phenomenon in the human medical literature, which can arise from previous injury to an area, inflammatory reactions, or previous overstimulation of the stress axes. A number of events that occur prior to arrival at, or in the slaughterhouse, may lead to presence of these factors. This includes previous on-farm pathology, injuries arising from transport and handling and lack of habituation to humans. Whilst there is limited evidence of a direct effect of these on the processes of sensitisation in animals at slaughter, by analogy with the human neurobiology literature the connection seems plausible. In this review a neurobiological approach is taken to discuss this hypothesis in the light of basic science, and extrapolations from existing literature on the slaughter of ruminants. To confirm the postulated link between events at slaughter, and processes of hypersensitisation, further dedicated study is required.
基于神经生物学检查，我们认为，屠宰前后发生的事件有可能通过敏化和增强传递过程加剧疼痛反应。敏化，即对疼痛刺激的增强反应，是人类医学文献中充分讨论过的一种现象，它可能源于先前某个部位的损伤、炎症反应或先前对应激轴的过度刺激。在到达屠宰场之前或在屠宰场内发生的一些事件，可能会导致这些因素的存在。这包括先前在农场的疾病、运输和处理过程中产生的损伤以及对人类缺乏适应。虽然这些因素对屠宰动物敏化过程的直接影响证据有限，但类比人类神经生物学文献，这种联系似乎是合理的。在本综述中，采用神经生物学方法，根据基础科学以及从现有反刍动物屠宰文献中得出的推断来讨论这一假设。为了证实屠宰时的事件与超敏化过程之间的假定联系，还需要进一步的专门研究。
