Srinivasan A R, Yathindra N
Nucleic Acids Res. 1977 Nov;4(11):3969-79. doi: 10.1093/nar/4.11.3969.
A novel description of the conformational characteristics of all the individual nucleotides and the phosphodiesters in tRNAs is presented in the form of a circular plot. This representation furnishes information of the base sequence with the folding patterns of the polynucleotide chain as one traverses along the circumference and with the individual nucleotide and phosphodiester linkage torsions along the radii. The circular plot obtained for yeast tRNAPhe strikingly distinguishes the helical and the loop regions. The variation of the different nucleotide torsions along the entire chain length and their effect on the secondary helical and tertiary loop regions become readily apparent.
以圆形图的形式给出了对tRNA中所有单个核苷酸和磷酸二酯的构象特征的全新描述。这种表示方式提供了碱基序列的信息，其中随着沿着圆周移动，多核苷酸链的折叠模式以及沿着半径的单个核苷酸和磷酸二酯键扭转情况都得以呈现。为酵母苯丙氨酸tRNA获得的圆形图显著地区分了螺旋区和环区。沿着整个链长不同核苷酸扭转的变化及其对二级螺旋区和三级环区的影响变得一目了然。
