核酸中的链折叠机制。酵母苯丙氨酸tRNA1中的（ω，ω）图及其与核苷酸几何结构的相关性。
Mechanisms of chain folding in nucleic acids. The (omega, omega) plot and its correlation to the nucleotide geometry in yeast tRNAPhe1.
作者信息
Sundaralingam M, Mizuno H, Stout C D, Rao S T, Liedman M, Yathindra N
出版信息
Nucleic Acids Res. 1976 Oct;3(10):2471-84. doi: 10.1093/nar/3.10.2471.
Abstract
The (omega', omega) polot depicting the internucleotide P-O bond rotation angles in yeast phenylalanyl transfer RNA has established the interdependence of the phosphodiesters and the nucleotide geometries in the folding of the polynucleotide backbone. The plot distinguishes the regions characteristic of secondary helical structures and tertiary structural loops and bends. The folding of the polynucleotide chain is accomplished either solely by rotations around the P-O bonds or in concert with rotations around the nucleotide C4'-C5' bond with or without changes in the sugar ring pucker. In spite of differences in nucleotide sequence and intraloop tertiary interactions in the anticodon and pseudouridine loops, a characteristic repeating structural unit is found for the sugar-phosphate backbone of the tetranucleotide segment around the sharp turns.
摘要
描绘酵母苯丙氨酰转移RNA中核苷酸间P - O键旋转角度的(ω′, ω)图，确立了多核苷酸主链折叠中磷酸二酯键与核苷酸几何结构之间的相互依存关系。该图区分了二级螺旋结构以及三级结构环和弯折的特征区域。多核苷酸链的折叠要么仅通过围绕P - O键的旋转来完成，要么与围绕核苷酸C4′- C5′键的旋转协同进行，同时糖环构象可能发生或不发生变化。尽管反密码子环和假尿苷环中的核苷酸序列以及环内三级相互作用存在差异，但在急转弯周围的四核苷酸片段的糖 - 磷酸主链中发现了一个特征性的重复结构单元。
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